(R)-γ-羟甲基-γ-丁内酯 (R)-4,5-二氢-5-羟甲基-2(3H)-呋喃酮 (R)-5-羟甲基-2-氧代四氢呋喃合成路线 （共 44 条）
反应条件
1: 0.65 M aq. NaOIO4, SiO2 / CH2Cl2 / 0.25 h 2: NaBH4 / methanol / 1 h / -30 - -15 °C View Scheme
参考文献
Rassu, Gloria; Zanardi, Franca; Battistini, Lucia; Gaetani, Enrico; Casiraghi, Giovanni
Journal of Medicinal Chemistry, 1997 , vol. 40, # 2 p. 168 - 180
反应条件
1: 80percent aq. acetic acid / 8 h / 50 °C 2: 0.65 M aq. NaOIO4, SiO2 / CH2Cl2 / 0.25 h 3: NaBH4 / methanol / 1 h / -30 - -15 °C View Scheme
参考文献
Rassu, Gloria; Zanardi, Franca; Battistini, Lucia; Gaetani, Enrico; Casiraghi, Giovanni
Journal of Medicinal Chemistry, 1997 , vol. 40, # 2 p. 168 - 180
参考文献
Zarbin, Paulo H.G.; Oliveira, Alfredo R.M.; Simonelli, Fabio; Villar, Jose A.F.P.; Delay Jr., Orlando
Tetrahedron Letters, 2004 , vol. 45, # 40 p. 7399 - 7400
反应条件
1: 70 percent / NaNO2, H3O(1+) / H2O 2: 98 percent / BH3*Me2S / tetrahydrofuran View Scheme
参考文献
Harmange, Jean-Christophe; Figadere, Bruno; Hocquemiller, Reynald
Tetrahedron: Asymmetry, 1991 , vol. 2, # 5 p. 347 - 350
反应条件
1: 2M NaOH / diethyl ether 2: 47 percent / sucrose / H2O / 12 h / 30 °C 3: 93 percent / Amberlyst 15 / 0.5 h / 25 °C View Scheme
参考文献
Ramaswamy, Sowmianarayanan; Oehlschlager, Allan C.
Tetrahedron, 1991 , vol. 47, # 7 p. 1145 - 1156
反应条件
1: 68 percent / sucrose / H2O / 24 h / 30 °C / baker's yeast 2: 92 percent / Amberlyst 15 / 0.5 h / Ambient temperature View Scheme
参考文献
Ramaswamy, Sowmianarayanan; Oehlschlager, Allan C.
Tetrahedron, 1991 , vol. 47, # 7 p. 1145 - 1156
反应条件
1: Jones reagent / acetone / 0.5 h / 10 °C 2: 2M NaOH / diethyl ether 3: 47 percent / sucrose / H2O / 12 h / 30 °C 4: 93 percent / Amberlyst 15 / 0.5 h / 25 °C View Scheme
参考文献
Ramaswamy, Sowmianarayanan; Oehlschlager, Allan C.
Tetrahedron, 1991 , vol. 47, # 7 p. 1145 - 1156
反应条件
1: 47 percent / sucrose / H2O / 12 h / 30 °C 2: 93 percent / Amberlyst 15 / 0.5 h / 25 °C View Scheme
参考文献
Ramaswamy, Sowmianarayanan; Oehlschlager, Allan C.
Tetrahedron, 1991 , vol. 47, # 7 p. 1145 - 1156
反应条件
1: 63 percent / iodomethane, NaHCO3 / H2O; acetonitrile / 48 h / Ambient temperature 2: 68 percent / sucrose / H2O / 24 h / 30 °C / baker's yeast 3: 92 percent / Amberlyst 15 / 0.5 h / Ambient temperature View Scheme
参考文献
Ramaswamy, Sowmianarayanan; Oehlschlager, Allan C.
Tetrahedron, 1991 , vol. 47, # 7 p. 1145 - 1156
反应条件
1: NaIO4; silica gel / H2O; CH2Cl2 / 20 °C 2: NaBH4 / methanol / 0.17 h / 0 °C View Scheme
参考文献
Nakada, Masahisa; Takano, Masashi; Iwata, Yukitaka
Chemical and Pharmaceutical Bulletin, 2000 , vol. 48, # 10 p. 1581 - 1585
