potassium hydroxide in ethanol; water T=20°C; 18 h;
参考文献
Block, Michael Howard; Donald, Craig Samuel; Brittain, David Robert; Foote, Kevin Michael
Patent: US2003/225097 A1, 2003 ;
Location in patent: Page 51 ;
1: sodium wire / diethyl ether / 18 h / Ambient temperature
2: ethanol / 7 h / Heating
3: 79 percent / NaOH / H2O; ethanol / 60 °C
4: 40 percent / 2.) ethanolic hydrogen chloride / 5 h / 145 - 150 °C
View Scheme
参考文献
Brown, Thomas H.; Blakemore, Robert C.; Blurton, Peter; Durant, Graham J.; Ganellin, C. Robin; et al.
European Journal of Medicinal Chemistry, 1989 , vol. 24, p. 65 - 72
Brown, Thomas H.; Blakemore, Robert C.; Blurton, Peter; Durant, Graham J.; Ganellin, C. Robin; et al.
European Journal of Medicinal Chemistry, 1989 , vol. 24, p. 65 - 72