3-溴-4-羟基-5-甲氧基苯甲腈合成路线 （共 8 条）
反应条件
formic acid; hydroxylammonium sulphate; sodium formate T=90°C; 7.5 h; Inert atmosphere;
参考文献
Wang, Chen; Dong, Jinyun; Zhang, Yanmin; Wang, Fang; Gao, Hongping; Li, Pengfei; Wang, Sicen; Zhang, Jie
MedChemComm, 2013 , vol. 4, # 11 p. 1434 - 1438
反应条件
[{RuCl2(p-cymene)}2]; diphenyl acetylene in isopropyl alcohol T=100°C; 16 h; Inert atmosphere; regioselective reaction;
参考文献
Chinnagolla, Ravi Kiran; Pimparkar, Sandeep; Jeganmohan, Masilamani
Chemical Communications, 2013 , vol. 49, # 30 p. 3146 - 3148
反应条件
hydrogen; palladium on activated charcoal
参考文献
Vowinkel,E.; Bartel,J.
Chemische Berichte, 1974 , vol. 107, p. 1221 - 1227
反应条件
1: (i) NH2OH*HCl, Py, (ii) DCC, CuSO4*5H2O, Et3N 2: H2 / Pd-C View Scheme
参考文献
Vowinkel,E.; Bartel,J.
Chemische Berichte, 1974 , vol. 107, p. 1221 - 1227
反应条件
1.1: sodium acetate; iron / acetic acid / 0.5 h / 20 °C 1.2: 23 - 258 °C 2.1: sodium formate / formic acid / 90 °C 2.2: 5 h / 90 °C View Scheme
参考文献
Wang, Chen; Gao, Hongping; Dong, Jinyun; Zhang, Yanmin; Su, Ping; Shi, Yaling; Zhang, Jie
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 1 p. 277 - 284
参考文献
Brady; Dunn
Journal of the Chemical Society, 1915 , vol. 107, p. 1859
反应条件
1: 5-bromo-4-hydroxy-3-methoxybenzonitrile With potassium carbonate in acetone T=50°C; 0.5 h; Inert atmosphere; 2: dimethyl sulfate in acetone T=50°C; Inert atmosphere;
参考文献
Wang, Chen; Dong, Jinyun; Zhang, Yanmin; Wang, Fang; Gao, Hongping; Li, Pengfei; Wang, Sicen; Zhang, Jie
MedChemComm, 2013 , vol. 4, # 11 p. 1434 - 1438
参考文献
Brady; Dunn
Journal of the Chemical Society, 1915 , vol. 107, p. 1859
