(3-氰基苯基)乙酸甲酯合成路线 （共 18 条）
反应条件
tetrakis(triphenylphosphine) palladium(0) in DMF (N,N-dimethyl-formamide) T=90°C; 2 h;
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: EP1479681 A1, 2004 ;
Location in patent: Page 112 ;
反应条件
sulfuric acid T=20 - 70°C; 3 h; Inert atmosphere;
参考文献
Gruenenthal GmbH; FRANK, Robert; Bahrenberg, Gregor; Christoph, Thomas; Lesch, Bernhard; Lee, Jeewoo
Patent: US2013/79320 A1, 2013 ;
Location in patent: Paragraph 0457; 0458; 0465; 0466 ;
反应条件
in N,N-dimethyl-formamide 18 h; Reflux;
参考文献
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH; BRESLOW, Ronald; MARKS, Paul, A.
Patent: WO2013/52110 A1, 2013 ;
Location in patent: Page/Page column 63; 64 ;
反应条件
in methanol; N,N-dimethyl-formamide
参考文献
US2014/142081 A1, ;
Page/Page column ;
反应条件
tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide T=80°C; 30 h;
参考文献
Epple, Robert; Azimioara, Mihai; Russo, Ross; Xie, Yongping; Wang, Xing; Cow, Christopher; Wityak, John; Karanewsky, Don; Bursulaya, Badry; Kreusch, Andreas; Tuntland, Tove; Gerken, Andrea; Iskandar, Maya; Saez, Enrique; Martin Seidel; Tian, Shin-Shay
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 21 p. 5488 - 5492
反应条件
1: H2SO4 / Heating 2: dimethylformamide / Heating View Scheme
参考文献
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH; BRESLOW, Ronald; MARKS, Paul, A.
Patent: WO2013/52110 A1, 2013 ;
反应条件
1: 100 percent / H2SO4 / 8 h / Heating 2: NEt3 / CH2Cl2 / 1 h / 0 °C 3: Pd(PPh3)4 / dimethylformamide / 30 h / 80 °C View Scheme
参考文献
Epple, Robert; Azimioara, Mihai; Russo, Ross; Xie, Yongping; Wang, Xing; Cow, Christopher; Wityak, John; Karanewsky, Don; Bursulaya, Badry; Kreusch, Andreas; Tuntland, Tove; Gerken, Andrea; Iskandar, Maya; Saez, Enrique; Martin Seidel; Tian, Shin-Shay
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 21 p. 5488 - 5492
反应条件
1: NEt3 / CH2Cl2 / 1 h / 0 °C 2: Pd(PPh3)4 / dimethylformamide / 30 h / 80 °C View Scheme
参考文献
Epple, Robert; Azimioara, Mihai; Russo, Ross; Xie, Yongping; Wang, Xing; Cow, Christopher; Wityak, John; Karanewsky, Don; Bursulaya, Badry; Kreusch, Andreas; Tuntland, Tove; Gerken, Andrea; Iskandar, Maya; Saez, Enrique; Martin Seidel; Tian, Shin-Shay
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 21 p. 5488 - 5492
反应条件
2: 1.) BuLi, 2.) cc HCl / 1.) THF, -78 deg C, 40 min, 2.) EtOH, -78 deg C, 15 min, r.t. 3: 1.02 g / SOCl2 / toluene / 1 h / 100 °C 4: NH3 / tetrahydrofuran / 0.5 h / 0 °C 5: POCl3 / 0.67 h / 100 °C 6: methanol / 0.5 h / -20 °C View Scheme
参考文献
Gokhale, Abha; Schiess, Peter
Helvetica Chimica Acta, 1998 , vol. 81, # 2 p. 251 - 267
反应条件
1: 1.02 g / SOCl2 / toluene / 1 h / 100 °C 2: NH3 / tetrahydrofuran / 0.5 h / 0 °C 3: POCl3 / 0.67 h / 100 °C 4: methanol / 0.5 h / -20 °C View Scheme
参考文献
Gokhale, Abha; Schiess, Peter
Helvetica Chimica Acta, 1998 , vol. 81, # 2 p. 251 - 267
