4-(4-氨基苯基) -1,2,4-三唑合成路线 (共 6 条)
参考文献
Merck, Sharp and Dohme Ltd.
Patent: US5554629 A1, 1996 ;
反应条件
hydrogenchloride
Heating;
参考文献
Sternfeld, Francine; Baker, Raymond; Broughton, Howard B.; Guiblin, Alexander R.; Jelley, Richard A.; Matassa, Victor G.; Reeve, Austin J.; Beer, Margaret S.; Stanton, Josephine A.; Hargreaves, Richard J.; Shepheard, Sara L.; Longmore, Jeanette; Razzaque, Zerin; Graham, Michael I.; Sohal, Bindi; Street, Leslie J.
Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 15 p. 1825 - 1830
反应条件
1: 90 percent / H2, 2N HCl / Pd-C / ethanol; ethyl acetate
2: 91 percent / TsOH*H2O / toluene / Heating
3: 76 percent / 5N HCl / Heating
View Scheme
参考文献
Sternfeld, Francine; Baker, Raymond; Broughton, Howard B.; Guiblin, Alexander R.; Jelley, Richard A.; Matassa, Victor G.; Reeve, Austin J.; Beer, Margaret S.; Stanton, Josephine A.; Hargreaves, Richard J.; Shepheard, Sara L.; Longmore, Jeanette; Razzaque, Zerin; Graham, Michael I.; Sohal, Bindi; Street, Leslie J.
Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 15 p. 1825 - 1830
反应条件
hydrogen; palladium on activated charcoal in ethanol
参考文献
Elguero, Jose; Gil, Manuel; Iza, Nerea; Pardo, Carmen; Ramos, Mar
Applied Spectroscopy, 1995 , vol. 49, # 8 p. 1111 - 1119
反应条件
1: 91 percent / pTsOH*H2O / toluene / 17 h / Heating
2: 76 percent / 5 N HCl / 1.5 h / 125 °C
View Scheme
参考文献
Sternfeld, Francine; Guiblin, Alexander R.; Jelley, Richard A.; Matassa, Victor G.; Reeve, Austin J.; Hunt, Peter A.; Beer, Margaret S.; Heald, Anne; Stanton, Josephine A.; Sohal, Bindi; Watt, Alan P.; Street, Leslie J.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 4 p. 677 - 690
反应条件
in benzene
7 h; Heating;
参考文献
Naik, Anil D.; Marchand-Brynaert, Jacqueline; Garcia, Yann
Synthesis, 2008 , # 1 p. 149 - 154