1-苯甲酰哌啶-4-羧酸合成路线 （共 10 条）
反应条件
1: With potassium carbonate in tetrahydrofuran; water T=0 - 20°C; 22 h; 2: With hydrogenchloride in water T=0°C; pH=1 - 2;
参考文献
Kosak, Urban; Brus, Boris; Gobec, Stanislav
Tetrahedron Letters, 2014 , vol. 55, # 12 p. 2037 - 2039
参考文献
Efange, Simon M. N.; Khare, Anil B.; Von Hohenberg, Krystyna; MacH, Robert H.; Parsons, Stanley M.; Tu, Zhude
Journal of Medicinal Chemistry, 2010 , vol. 53, # 7 p. 2825 - 2835
反应条件
1: Et3N 2: aq. NaOH View Scheme
参考文献
Shao, Dong; Zou, Chunyan; Luo, Cheng; Tang, Xican; Li, Yuanchao
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 18 p. 4639 - 4642
反应条件
1: Et3N 2: aq. NaOH View Scheme
参考文献
Shao, Dong; Zou, Chunyan; Luo, Cheng; Tang, Xican; Li, Yuanchao
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 18 p. 4639 - 4642
反应条件
1: DCC 2: aq. NH3 3: 73.6 percent / LiAlH4 / tetrahydrofuran / Heating View Scheme
参考文献
Shao, Dong; Zou, Chunyan; Luo, Cheng; Tang, Xican; Li, Yuanchao
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 18 p. 4639 - 4642
反应条件
potassium borohydride; magnesium chloride in tetrahydrofuran; toluene T=100°C; 2 h;
参考文献
Qiu, You-Chun; Zhang, Fu-Li; Zhang, Chun-Nian
Tetrahedron Letters, 2007 , vol. 48, # 43 p. 7595 - 7598
反应条件
thionyl chloride; sodium carbonate in diethyl ether T=20°C; Substitution; 22 h;
参考文献
Tan, Ping-Zhong; Baldwin, Ronald M.; Fu, Tao; Charney, Dennis S.; Innis, Robert B.
Journal of Labelled Compounds and Radiopharmaceuticals, 1999 , vol. 42, # 5 p. 457 - 467
反应条件
sodium borohydride; triethylamine in tetrahydrofuran; hexane; water; ethyl acetate; N,N-dimethyl-formamide
参考文献
Merck and Co., Inc.
Patent: US6248755 B1, 2001 ;
US 6248755 B1
反应条件
PdCl2(nbd); acetic anhydride; triphenylphosphine; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene in neat (no solvent)
T=132°C; 1.5 h; Inert atmosphere;
参考文献
Liu, Yiyang; Kim, Kelly E.; Herbert, Myles B.; Fedorov, Alexey; Grubbs, Robert H.; Stoltz, Brian M.
Advanced Synthesis and Catalysis, 2014 , vol. 356, # 1 p. 130 - 136
反应条件
bis-triphenylphosphine-palladium(II) chloride; 3,3',5,5'-tetra-tert-butyl-2,2'-di-hydroxy-1,1'-biphenyl; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene in neat (no solvent)
T=132°C; 1.5 h; Inert atmosphere; Overall yield = 80 percent;
参考文献
Liu, Yiyang; Kim, Kelly E.; Herbert, Myles B.; Fedorov, Alexey; Grubbs, Robert H.; Stoltz, Brian M.
Advanced Synthesis and Catalysis, 2014 , vol. 356, # 1 p. 130 - 136
