3-(三甲基硅基)丙炔醇合成路线 （共 67 条）
反应条件
2-methylpropylmagnesium bromide; bis(cyclopentadienyl)titanium dichloride
1.) Ether, 0 to 25 deg C 2.) Ether, room temp.; Yield given. Multistep reaction;
参考文献
Sato, Fumie; Katsuno, Harutaka
Tetrahedron Letters, 1983 , vol. 24, # 17 p. 1809 - 1810
反应条件
2-methylpropylmagnesium bromide; bis(cyclopentadienyl)titanium dichloride
1.) Ether, 0 to 25 deg C 2.) Ether, room temp.; Yield given. Multistep reaction;
参考文献
Sato, Fumie; Katsuno, Harutaka
Tetrahedron Letters, 1983 , vol. 24, # 17 p. 1809 - 1810
反应条件
2-methylpropylmagnesium bromide; bis(cyclopentadienyl)titanium dichloride
1.) Ether, 0 to 25 deg C 2.) Ether, room temp.; Yield given. Multistep reaction;
参考文献
Sato, Fumie; Katsuno, Harutaka
Tetrahedron Letters, 1983 , vol. 24, # 17 p. 1809 - 1810
反应条件
1: With sodium bis(2-methoxyethoxy)aluminium dihydride in diethyl ether; toluene
T=0 - 20°C; 2 h;
2: With N-bromosuccinmide in diethyl ether; toluene
T=0°C;
参考文献
Rogers, Lawrence R.; Konstantinou, Zissis; Reddy, Madhav; Organ, Michael G.
European Journal of Organic Chemistry, 2011 , # 27 p. 5374 - 5382
反应条件
triethylamine in diethyl ether
T=-20°C;
参考文献
Cutting, Ian; Parsons, Philip J.
Tetrahedron Letters, 1983 , vol. 24, # 41 p. 4463 - 4464
反应条件
1: 82 percent / CrO3 / acetone; aq. H2SO4 / 14 h / Ambient temperature
2: 88 percent / H2, quinoline / Lindlar-cat. / hexane / Ambient temperature
View Scheme
参考文献
Hermeling, Dieter; Schaefer, Hans J.
Chemische Berichte, 1988 , vol. 121, p. 1151 - 1158
反应条件
1: 78 percent / LiAlH4
2: 79 percent / CrO3 / acetone; aq. H2SO4 / 14 h / Ambient temperature
3: 92 percent / Cl2OS / Heating
View Scheme
参考文献
Wilson; Di Grandi
Journal of Organic Chemistry, 1991 , vol. 56, # 15 p. 4766 - 4772
反应条件
1: 82 percent / CrO3 / acetone; aq. H2SO4 / 14 h / Ambient temperature
2: 88 percent / H2, quinoline / Lindlar-cat. / hexane / Ambient temperature
3: 12 h / 90 °C
View Scheme
参考文献
Hermeling, Dieter; Schaefer, Hans J.
Chemische Berichte, 1988 , vol. 121, p. 1151 - 1158
反应条件
1: 45 percent / Et3N / diethyl ether / -20 °C
2: 59 percent / LiAlH4 / diethyl ether / -50 °C
View Scheme
参考文献
Cutting, Ian; Parsons, Philip J.
Tetrahedron Letters, 1983 , vol. 24, # 41 p. 4463 - 4464
反应条件
1: imidazole; I2; PPh3 / CH2Cl2 / 1 h / Heating
2: 72 percent / CH2Cl2 / 3 h / 20 °C
3: 100 percent / MCPBA / CH2Cl2 / 20 °C
View Scheme
参考文献
Bonini, Carlo; Chiummiento, Lucia; Videtta, Valeria
Synlett, 2005 , # 20 art. no. G29805ST, p. 3067 - 3070
