4-氨基-3-氯苯酚盐酸盐合成路线 （共 5 条）
反应条件
1: With sulfuric acid; boric acid; iron(II) sulfate in nitrobenzene T=120 - 150°C; 22 h; 2: With potassium carbonate in water; nitrobenzene
参考文献
Wyeth
Patent: US2007/27160 A1, 2007 ;
Location in patent: Page/Page column 43 ;
US 20070027160 A1
反应条件
sulfuric acid; boric acid; iron(II) sulfate in glycerol T=0 - 150°C; 22 h;
参考文献
WYETH
Patent: WO2007/146116 A2, 2007 ;
Location in patent: Page/Page column 28 ;
反应条件
1: 3-chloro-4-amino phenol hydrochloride With potassium tert-butylate; potassium carbonate in acetone T=20°C; 2: methyl iodide in acetone T=20°C; 2 h;
参考文献
SB PHARMCO PUERTO RICO INC; NEUROCRINE BIOSCIENCES INC; GLAXO GROUP LIMITED
Patent: WO2004/62665 A1, 2004 ;
Location in patent: Page/Page column 38 ;
WO 2004/062665 A1
反应条件
sodium acetate; acetic acid
T=125°C; 2 h;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Patent: US2012/88755 A1, 2012 ;
Location in patent: Page/Page column 74 ;
反应条件
sodium acetate; sodium hydrogencarbonate in acetic acid
参考文献
Dupont Pharmaceuticals Company
Patent: US6143743 A1, 2000 ;
US 6143743 A
