1,4,7-三对甲苯磺酰基-1,4,7-三氮杂环壬烷合成路线 （共 21 条）
反应条件
1: With sulfuric acid in water T=140°C; 20 h; 2: With sodium hydroxide in water; toluene 2 h; Heating;
参考文献
Kramer, Jurjen; Scholten, Arjen; Driessen, Willem L.; Reedijk, Jan
European Journal of Inorganic Chemistry, 2002 , # 6 p. 1488 - 1494
反应条件
1: tri-Ts-1,4,7-triazacyclononane With sulfuric acid in water T=140°C; 6 h; 2: With sodium hydroxide in water Cooling with ice; 3: formaldehyd With formic acid in water T=90°C;
参考文献
US7674866 B2, ;
Page/Page column 17 ;
反应条件
1: With hydrogenchloride; water T=140°C; 6 h; 2: With sodium hydroxide; formaldehyd; formic acid in water T=0 - 90°C; Further stages.;
参考文献
Chemical Communications, , # 18 p. 1855 - 1857
反应条件
1: With sulfuric acid T=100°C; 72 h; Inert atmosphere; 2: With sodium hydroxide in water Inert atmosphere; 3: With hydrogenchloride in water pH=1;
参考文献
Eitel, Simon H.; Bauer, Matthias; Schweinfurth, David; Deibel, Naina; Sarkar, Biprajit; Kelm, Harald; Krueger, Hans-Joerg; Frey, Wolfgang; Peters, Rene
Journal of the American Chemical Society, 2012 , vol. 134, # 10 p. 4683 - 4693
反应条件
hydrogen bromide; acetic acid Heating;
参考文献
Lazar; Takacs
Synthetic Communications, 2001 , vol. 31, # 20 p. 3141 - 3144
反应条件
1: 83 percent / PhOH; HBr; AcOH / 36 h / 90 °C
2: 94 percent / Na2CO3 / acetonitrile / 18 h / Heating
3: 60 percent / H2SO4 / 18 h / 120 °C
View Scheme
参考文献
Cheng, Chien-Chung; Huang, Yan-Chen; Liu, Ming-Chan
Journal of the Chinese Chemical Society, 2004 , vol. 51, # 5 B p. 1201 - 1208
反应条件
1: 65 percent / conc. H2SO4 / 120 h / 120 °C
2: 16 percent / POCl3, Et3N / benzene / 2 h / Ambient temperature
View Scheme
参考文献
Bourne, Susan A.; Mbianda, Xavier Y.; Modro, Tomasz A.; Nassimbeni, Luigi R.; Wan, Huijie
Journal of the Chemical Society. Perkin Transactions 2, 1998 , # 1 p. 83 - 88
反应条件
1.1: aq. H2SO4; HBr / 48 h / 90 °C
1.2: 61 percent / NaOH / toluene / 24 h / Heating
2.1: 85 percent / 5 h / Heating
3.1: 80 percent / acetonitrile / 12 h / 20 °C
4.1: H2O / 3 h / Heating
4.2: 74 percent / KOH / ethanol / 48 h / Heating
View Scheme
参考文献
UNILEVER PLC; UNILEVER N.V.; HINDUSTAN LEVER LIMITED; HAGE, Ronald; KOEK, Jean Hypolites; RUSSELL, Stephen William; WANG, Xiaohong; WOLF, Lodewijk van der; ZHANG, Jianrong; ZHAO, Wei
Patent: WO2012/3712 A1, 2012 ;
反应条件
sodium hydride in various solvents; N,N-dimethyl-formamide
T=105°C; 8 h;
参考文献
Gao, Jinzhang; He, Hui; Zhang, Xuan; Lu, Xiaoquan; Kang, Jingwan
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2002 , vol. 41, # 2 p. 372 - 375
反应条件
in N,N-dimethyl-formamide
T=100°C; 3 h;
参考文献
Hasserodt, Jens
Patent: US2007/218010 A1, 2007 ;
Location in patent: Page/Page column 14; 19 ;
