1,4,7,10-四甲苯磺酰-1,4,7,10-四氮杂环十二烷合成路线 （共 22 条）
反应条件
1: 78 percent / 4 N NaOH / diisopropyl ether; H2O / 1.) r.t., 15 h, 2.) pH 11, ca. 80 deg C, 30 min 2: 91 percent / sodium ethoxide / ethanol / 1 h / Heating 3: 67 percent / dimethylformamide / 1 h / Heating View Scheme
参考文献
Das, Tapas; Chakraborty, Sudipta; Banerjeel, Sharmila; Samuel, Grace; Sarma; Venkatesh, Meera; Pillai
Journal of Labelled Compounds and Radiopharmaceuticals, 2003 , vol. 46, # 3 p. 197 - 209
反应条件
1: 76 percent / sodium hydroxide / H2O / 1.) 5 deg C, 1 hr., 2.) 3 hrs., r.t. 2: 90 percent / tetrabutylammonium iodide, sodium hydroxide (50 percent) / toluene; H2O / 9 h / Heating View Scheme
参考文献
Luk'yanenko, N.G.; Basok, S.S.; Filonova, L.K.
Journal of Organic Chemistry USSR (English Translation), 1988 , vol. 24, p. 1562 - 1571
Zhurnal Organicheskoi Khimii, 1988 , vol. 24, # 8 p. 1731 - 1742
反应条件
1: pyridine / 2 h / Ambient temperature 2: Na2CO3 / acetonitrile / 144 h / Heating View Scheme
参考文献
Springborg, Johan; Kofod, Pauli; Olsen, Carl Erik; Toftlund, Hans; Soetofte, Inger
Acta Chemica Scandinavica, 1995 , vol. 49, # 8 p. 547 - 554
反应条件
1: 91 percent / sodium ethoxide / ethanol / 1 h / Heating 2: 67 percent / dimethylformamide / 1 h / Heating View Scheme
参考文献
Swinkels, Dorine W.; Duynhoven, John P. M. van; Hilbers, Cornelis W.; Tesser, Godefridus I.
Recueil des Travaux Chimiques des Pays-Bas, 1991 , vol. 110, # 4 p. 124 - 128
反应条件
sodium carbonate in acetonitrile 144 h; Heating; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Springborg, Johan; Kofod, Pauli; Olsen, Carl Erik; Toftlund, Hans; Soetofte, Inger
Acta Chemica Scandinavica, 1995 , vol. 49, # 8 p. 547 - 554
反应条件
pyridine 2 h; Ambient temperature; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Springborg, Johan; Kofod, Pauli; Olsen, Carl Erik; Toftlund, Hans; Soetofte, Inger
Acta Chemica Scandinavica, 1995 , vol. 49, # 8 p. 547 - 554
反应条件
sulfuric acid in water 0.0138889 h; microwave irradiation;
参考文献
Wei; Shi; He; Ma
Polish Journal of Chemistry, 2003 , vol. 77, # 4 p. 485 - 487
反应条件
sulfuric acid T=165°C;
参考文献
Wilson, Jennifer M.; Giordani, Federica; Farrugia, Louis J.; Barrett, Michael P.; Robins, David J.; Sutherland, Andrew
Organic and Biomolecular Chemistry, 2007 , vol. 5, # 22 p. 3651 - 3656
反应条件
1: 33 percent / conc. H2SO4 / 28 h / 115 °C 2: 88 percent / NaOH / H2O / 30 h / 70 °C / pH 9.5 - 10 View Scheme
参考文献
Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 46, # 3 p. 197 - 209
反应条件
hydrogenchloride; sulfuric acid; Amberlyst A26 T=120°C; 48 h;
参考文献
Hettich, Ronald; Schneider, Hans-Joerg
Journal of the American Chemical Society, 1997 , vol. 119, # 24 p. 5638 - 5647
