5-氰基-1,6-二氢-2-甲基-6-氧代-3-吡啶羧酸乙酯合成路线 （共 5 条）
反应条件
1: 98 percent / KOH / aq. ethanol / 4 h / Heating 2: 57 percent / copper powder / quinoline / 3 h / Heating View Scheme
参考文献
Mosti; Menozzi; Schenone; Dorigo; Gaion; Benetollo; Bombieri
European Journal of Medicinal Chemistry, 1989 , vol. 24, # 5 p. 517 - 529
反应条件
potassium hydroxide in ethanol 4 h; Heating;
参考文献
ASTRAZENECA AB
Patent: WO2007/8140 A1, 2007 ;
Location in patent: Page/Page column 173 ;
WO 2007/008140 A1
反应条件
sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride
参考文献
American Hospital Supply Corporation
Patent: US4555517 A1, 1985 ;
反应条件
1: With potassium hydroxide; water in ethanol 12 h; Heating / reflux; 2: With hydrogenchloride in water
参考文献
ASTRAZENECA AB
Patent: US2008/176827 A1, 2008 ;
Location in patent: Page/Page column 19 ;
US 20080176827 A1
反应条件
oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane
18 h; Reflux;
参考文献
Bach, Peter; Bostroem, Jonas; Brickmann, Kay; Van Giezen; Groneberg, Robert D.; Harvey, Darren M.; O'Sullivan, Michael; Zetterberg, Fredrik
European Journal of Medicinal Chemistry, 2013 , vol. 65, p. 360 - 375
