2,5-二铵双环[2.2.1]庚烷二氯化物合成路线 （共 10 条）
反应条件
pyridine in 1,8-diazabicyclo[5.4.0]undec-7-ene
参考文献
Pfizer Inc.
Patent: US4861779 A1, 1989 ;
Title/Abstract Full Text Show Details
Pfizer Inc.
Patent: US4775668 A1, 1988 ;
反应条件
hydrogenchloride in 1,4-dioxane; methanol
T=20°C; 0.5 h;
参考文献
Beinat, Corinne; Banister, Samuel D.; McErlean, Christopher S.P.; Kassiou, Michael
Tetrahedron Letters, 2013 , vol. 54, # 39 p. 5345 - 5347
反应条件
hydrogenchloride; hydrogen; palladium on activated charcoal in methanol
P=4137.2 Torr; 3 h; Ambient temperature;
参考文献
Jordis; Sauter; Siddiqi; Kuenburg; Bhattacharya
Synthesis, 1990 , vol. 1, # 10 p. 925 - 930
反应条件
1: 79 percent / toluene / 18 h / Heating
2: 100 percent / hydrogen, conc. HCl / 10 percent Pd-C / methanol / 3 h / 4137.2 Torr / Ambient temperature
View Scheme
参考文献
Jordis; Sauter; Siddiqi; Kuenburg; Bhattacharya
Synthesis, 1990 , vol. 1, # 10 p. 925 - 930
反应条件
1.1: triethylamine / dichloromethane / 17 h / 0 °C
2.1: lithium borohydride / tetrahydrofuran / 26 h / 0 - 20 °C
3.1: pyridine / dichloromethane / 18 h / 40 °C
4.1: trimethylsilylazide; tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h / 70 °C
5.1: triethylamine / dichloromethane / 0.5 h / 0 °C
6.1: triphenylphosphine / tetrahydrofuran / 2 h / 20 °C
6.2: 18 h
7.1: hydrogenchloride / methanol; 1,4-dioxane / 0.5 h / 20 °C
View Scheme
参考文献
Beinat, Corinne; Banister, Samuel D.; McErlean, Christopher S.P.; Kassiou, Michael
Tetrahedron Letters, 2013 , vol. 54, # 39 p. 5345 - 5347
反应条件
1.1: thionyl chloride; hydrogenchloride / water / 18 h / 20 °C / |Reflux
2.1: triethylamine / dichloromethane / 17 h / 0 °C
3.1: lithium borohydride / tetrahydrofuran / 26 h / 0 - 20 °C
4.1: pyridine / dichloromethane / 18 h / 40 °C
5.1: trimethylsilylazide; tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h / 70 °C
6.1: triethylamine / dichloromethane / 0.5 h / 0 °C
7.1: triphenylphosphine / tetrahydrofuran / 2 h / 20 °C
7.2: 18 h
8.1: hydrogenchloride / methanol; 1,4-dioxane / 0.5 h / 20 °C
View Scheme
参考文献
Beinat, Corinne; Banister, Samuel D.; McErlean, Christopher S.P.; Kassiou, Michael
Tetrahedron Letters, 2013 , vol. 54, # 39 p. 5345 - 5347
反应条件
1.1: lithium borohydride / tetrahydrofuran / 26 h / 0 - 20 °C
2.1: pyridine / dichloromethane / 18 h / 40 °C
3.1: trimethylsilylazide; tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h / 70 °C
4.1: triethylamine / dichloromethane / 0.5 h / 0 °C
5.1: triphenylphosphine / tetrahydrofuran / 2 h / 20 °C
5.2: 18 h
6.1: hydrogenchloride / methanol; 1,4-dioxane / 0.5 h / 20 °C
View Scheme
参考文献
Beinat, Corinne; Banister, Samuel D.; McErlean, Christopher S.P.; Kassiou, Michael
Tetrahedron Letters, 2013 , vol. 54, # 39 p. 5345 - 5347
反应条件
1.1: pyridine / dichloromethane / 18 h / 40 °C
2.1: trimethylsilylazide; tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h / 70 °C
3.1: triethylamine / dichloromethane / 0.5 h / 0 °C
4.1: triphenylphosphine / tetrahydrofuran / 2 h / 20 °C
4.2: 18 h
5.1: hydrogenchloride / methanol; 1,4-dioxane / 0.5 h / 20 °C
View Scheme
参考文献
Beinat, Corinne; Banister, Samuel D.; McErlean, Christopher S.P.; Kassiou, Michael
Tetrahedron Letters, 2013 , vol. 54, # 39 p. 5345 - 5347
反应条件
1.1: trimethylsilylazide; tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h / 70 °C
2.1: triethylamine / dichloromethane / 0.5 h / 0 °C
3.1: triphenylphosphine / tetrahydrofuran / 2 h / 20 °C
3.2: 18 h
4.1: hydrogenchloride / methanol; 1,4-dioxane / 0.5 h / 20 °C
View Scheme
参考文献
Beinat, Corinne; Banister, Samuel D.; McErlean, Christopher S.P.; Kassiou, Michael
Tetrahedron Letters, 2013 , vol. 54, # 39 p. 5345 - 5347
反应条件
1.1: triethylamine / dichloromethane / 0.5 h / 0 °C
2.1: triphenylphosphine / tetrahydrofuran / 2 h / 20 °C
2.2: 18 h
3.1: hydrogenchloride / methanol; 1,4-dioxane / 0.5 h / 20 °C
View Scheme
参考文献
Beinat, Corinne; Banister, Samuel D.; McErlean, Christopher S.P.; Kassiou, Michael
Tetrahedron Letters, 2013 , vol. 54, # 39 p. 5345 - 5347
