N4-苯甲酰-2’-甲氧基胞苷合成路线 （共 9 条）
反应条件
sodium methylate in tetrahydrofuran; methanol 0.2 h; Ambient temperature;
参考文献
Chavis, C.; Dumont, F.; Wightman, R. H.; Ziegler, J. C.; Imbach, J. L.
Journal of Organic Chemistry, 1982 , vol. 47, # 2 p. 202 - 206
反应条件
silver(l) oxide in acetone T=20°C; 20 h;
参考文献
Gladkaya, V. A.; Levitskaya, Z. V.; Shalamai, A. S.; Usenko, L. S.; Dashevskaya, T. A.
Chemistry of Natural Compounds, 1989 , vol. 25, # 4 p. 488 - 492
反应条件
in N-methyl-acetamide; benzoic acid anhydride
参考文献
Isis Pharmceuticals, Inc.
Patent: US5646265 A1, 1997 ;
Title/Abstract Full Text Show Details
ISIS Pharmaceuticals, Inc.
Patent: US5914396 A1, 1999 ;
反应条件
1: 1.) HMDS, (NH4)2SO4, 2.) SnCl4 / 1.) reflux, overnight, 2.) dichloroethane, reflux, 60 min 2: 80 percent / NaOCH3 / tetrahydrofuran; methanol / 0.2 h / Ambient temperature View Scheme
参考文献
Chavis, C.; Dumont, F.; Wightman, R. H.; Ziegler, J. C.; Imbach, J. L.
Journal of Organic Chemistry, 1982 , vol. 47, # 2 p. 202 - 206
反应条件
1: 1.) HMDS, (NH4)2SO4, 2.) SnCl4 / 1.) reflux, overnight, 2.) dichloroethane, reflux, 60 min 2: 80 percent / NaOCH3 / tetrahydrofuran; methanol / 0.2 h / Ambient temperature View Scheme
参考文献
Chavis, C.; Dumont, F.; Wightman, R. H.; Ziegler, J. C.; Imbach, J. L.
Journal of Organic Chemistry, 1982 , vol. 47, # 2 p. 202 - 206
反应条件
1: 74 percent / BF3*(C2H5)2O / CH2Cl2 / 0 °C 2: 1.) HMDS, (NH4)2SO4, 2.) SnCl4 / 1.) reflux, overnight, 2.) dichloroethane, reflux, 60 min 3: 80 percent / NaOCH3 / tetrahydrofuran; methanol / 0.2 h / Ambient temperature View Scheme
参考文献
Chavis, C.; Dumont, F.; Wightman, R. H.; Ziegler, J. C.; Imbach, J. L.
Journal of Organic Chemistry, 1982 , vol. 47, # 2 p. 202 - 206
反应条件
tin(ll) chloride in N,N-dimethyl-formamide T=50°C; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Heikkilae, Jarmo; Bjoerkman, Sven; Oeberg, Bo; Chattopadhyaya, Jyoti
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1982 , vol. 36, # 10 p. 715 - 718
反应条件
1: 73 percent / pyridine / 2 h 2: 56 percent / silver oxide / acetone / 20 h / 20 °C View Scheme
参考文献
Gladkaya, V. A.; Levitskaya, Z. V.; Shalamai, A. S.; Usenko, L. S.; Dashevskaya, T. A.
Chemistry of Natural Compounds, 1989 , vol. 25, # 4 p. 488 - 492
反应条件
in ethanol 1 h; Heating;
参考文献
Metelev, Valerii G.; Krynetskaya, Natalya F.; Purmal, Andrei A.; Shabarova, Zoya A.; Tocik, Zdenek; et al.
Collection of Czechoslovak Chemical Communications, 1990 , vol. 55, # 11 p. 2781 - 2786
