3-叔丁氧羰基氨基-(S)-2-羟基丙酸合成路线 （共 4 条）
反应条件
sodium hydroxide in methanol
参考文献
Yang, Kanghui; Fen, Jinghong; Fang, Hao; Zhang, Lei; Gong, Jianzhi; Xu, Wenfang
Journal of Enzyme Inhibition and Medicinal Chemistry, 2012 , vol. 27, # 2 p. 302 - 310
反应条件
1: 3-amino-2-(S)-hydroxypropionic acid; di-tert-butyl dicarbonate With 4-methyl-morpholine in 1,4-dioxane; water
T=0 - 20°C;
2: glycine in 1,4-dioxane; water
0.333333 h;
参考文献
ACHAOGEN, INC.; AGGEN, James, Bradley; LINSELL, Martin, Sheringham; GOLDBLUM, Adam, Aaron; HILDEBRANDT, Darin, James; KANE, Timothy, Robert; DOZZO, Paola; GLIEDT, Micah, James; MOSER, Heinz, Ernst
Patent: WO2010/42850 A1, 2010 ;
Location in patent: Page/Page column 55-56 ;
WO 2010/042850 A1
反应条件
N-benzyl-trimethylammonium hydroxide in tetrahydrofuran; methanol
T=-40°C; 1 h;
参考文献
Andruszkiewicz, Ryszard; Wyszogrodzka, Monika
Synlett, 2002 , # 12 p. 2101 - 2103
反应条件
1: 85 percent / DMAP; Et3N / tetrahydrofuran / 5 - 10 °C
2: 75 percent / benzyltrimethylammonium hydroxide / tetrahydrofuran; methanol / 1 h / -40 °C
View Scheme
参考文献
Andruszkiewicz, Ryszard; Wyszogrodzka, Monika
Synlett, 2002 , # 12 p. 2101 - 2103
