2-[(4-甲氧基苯氨基)-甲基]-苯酚合成路线 （共 18 条）
反应条件
T=230°C; P=10 Torr; 0.0833333 h; pyrolysis without solvent, isolated as hydrochloride; Product distribution;
参考文献
Vinogradova, V. I.; Yunusov, M. S.
Chemistry of Natural Compounds, 1984 , vol. 20, # 3 p. 308 - 311
Khimiya Prirodnykh Soedinenii, 1984 , # 3 p. 331 - 334
反应条件
1: water; hydrochloric acid; sodium nitrite / 5 °C
2: NaOH-solution
View Scheme
参考文献
Hantzsch; Wechsler
Justus Liebigs Annalen der Chemie, 1902 , vol. 325, p. 249
反应条件
1: K2CO3 / ethanol / Heating
2: KI, cyclohexanol / Heating
View Scheme
参考文献
Shvedov,V.I. et al.
Pharmaceutical Chemistry Journal, 1979 , vol. 13, # 3 p. 256 - 260
Khimiko-Farmatsevticheskii Zhurnal, 1979 , vol. 13, # 3 p. 34 - 39
反应条件
sodium tetrahydroborate in methanol
0.5 h; Ambient temperature;
参考文献
Joglekar, S. J.; Samant, S. D.
Journal of the Indian Chemical Society, 1988 , vol. 65, p. 110 - 111
反应条件
1: in ethanol
0.5 h; Heating;
2: With sodium tetrahydroborate in ethanol
T=5 - 20°C;
参考文献
Davion, Yann; Guillaumet, Gerald; Leger, Jean-Michel; Jarry, Christian; Lesur, Brigitte; Merour, Jean-Yves
Heterocycles, 2003 , vol. 60, # 8 p. 1793 - 1804
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran
T=-78 - 20°C; 0.2 h; Inert atmosphere;
参考文献
Shaikh, Abdul Kadar; Cobb, Alexander J. A.; Varvounis, George
Organic Letters, 2012 , vol. 14, # 2 p. 584 - 587
反应条件
2: sodium amalgam; alcohol
View Scheme
参考文献
Hantzsch; Wechsler
Justus Liebigs Annalen der Chemie, 1902 , vol. 325, p. 249
反应条件
2: sodium amalgam; alcohol
View Scheme
参考文献
Hantzsch; Wechsler
Justus Liebigs Annalen der Chemie, 1902 , vol. 325, p. 249
反应条件
1: thionyl chloride; silver nitrate / tetrahydrofuran / 25 °C / Inert atmosphere
2: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.2 h / -78 - 20 °C / Inert atmosphere
View Scheme
参考文献
Shaikh, Abdul Kadar; Cobb, Alexander J. A.; Varvounis, George
Organic Letters, 2012 , vol. 14, # 2 p. 584 - 587
反应条件
1: 4-(N,N-dimethlyamino)pyridine; triethylamine / dichloromethane / 1 h / 0 °C / Inert atmosphere
2: sodium tetrahydroborate / methanol / 6 h / 20 °C / Inert atmosphere
3: thionyl chloride; silver nitrate / tetrahydrofuran / 25 °C / Inert atmosphere
4: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.2 h / -78 - 20 °C / Inert atmosphere
View Scheme
参考文献
Shaikh, Abdul Kadar; Cobb, Alexander J. A.; Varvounis, George
Organic Letters, 2012 , vol. 14, # 2 p. 584 - 587
