N-(三甲基硅基)-4-(三甲基硅氧基)-1,3,5-三嗪-2-胺合成路线 （共 8 条）
反应条件
1: With trifluorormethanesulfonic acid in acetonitrile T=55°C; 12.5 h; Industry scale; 2: With methanol; sodium methylate in dimethyl sulfoxide; acetonitrile T=22 - 23°C; 3.75 h;
参考文献
ScinoPharm Taiwan Ltd.
Patent: US2010/36112 A1, 2010 ;
Location in patent: Page/Page column 7 ;
反应条件
1: With tin(IV) chloride in 1,2-dichloro-ethane T=5 - 20°C; 2.25 h; 2: With water; sodium hydrogencarbonate in 1,2-dichloro-ethane T=15 - 20°C; 0.5 h; Product distribution / selectivity;
参考文献
CHEMAGIS LTD.
Patent: WO2009/16617 A2, 2009 ;
Location in patent: Page/Page column 15-16 ;
反应条件
1: With trifluorormethanesulfonic acid in acetonitrile T=0°C; 24 h; 2: With methanol; sodium methylate in dimethyl sulfoxide; acetonitrile T=20 - 23°C;
参考文献
ScinoPharm Taiwan Ltd.
Patent: US2010/36112 A1, 2010 ;
Location in patent: Page/Page column 7-8 ;
反应条件
1: With tin(IV) chloride in dichloromethane T=0 - 5°C; 6 h; Inert atmosphere; 2: With water; sodium hydrogencarbonate in dichloromethane T=10°C; 0.5 h; Product distribution / selectivity;
参考文献
PHARMION LLC; RAJENDIRAN, Chinnapillai; NAGARAJAN, Periyandi; VENKATESWARLAU, Jasti
Patent: WO2012/135405 A1, 2012 ;
Location in patent: Page/Page column 64-67 ;
反应条件
trifluorormethanesulfonic acid in acetonitrile T=20 - 25°C; Product distribution / selectivity;
参考文献
SICOR INC.; BIGATTI, Ettore; LUX, Giovanna; PAIOCCHI, Maurizio; GIOLITO, Andrea; TOSI, Simone
Patent: WO2010/17374 A1, 2010 ;
Location in patent: Page/Page column 17-18 ;
反应条件
1: With lithium trifluoromethane sulfonate in dichloromethane T=20 - 25°C; 4 h; 2: With water; sodium hydrogencarbonate in cyclohexane; ethyl acetate; acetonitrile T=0 - 30°C; 3 h;
参考文献
EP2050757 A1, ;
Page/Page column 3-4 ;
反应条件
1: With trimethylsilyl trifluoromethanesulfonate in chloroform T=1°C; 21 h; Inert atmosphere; 2: With sodium hydrogencarbonate in chloroform; water pH=6;
参考文献
US2010/249394 A1, ;
Page/Page column 5 ;
反应条件
ammonium sulfate
8 h; Reflux; Product distribution / selectivity;
参考文献
SICOR INC.; BIGATTI, Ettore; LUX, Giovanna; PAIOCCHI, Maurizio; GIOLITO, Andrea; TOSI, Simone
Patent: WO2010/17374 A1, 2010 ;
Location in patent: Page/Page column 18 ;
