8-氧代-1,4-二噁螺[4.5]癸烷-7-羧酸甲酯合成路线 （共 4 条）
反应条件
1: 1.) NaH / 1.) benzene, DMF, RT, 1 h, 2.) benzene, DMF, RT, 2 h
2: 86 percent / LiI / dimethylformamide / 6 h / 130 °C
View Scheme
参考文献
Kozikowski, Alan P.; Campiani, Giuseppe; Sun, Li-Qiang; Wang, Shaomeng; Saxena, Ashima; Doctor, Bhupendra P.
Journal of the American Chemical Society, 1996 , vol. 118, # 46 p. 11357 - 11362
反应条件
1: 1,4-cyclohexanedione monoacetal With sodium hydride in tetrahydrofuran
T=20°C; 0.5 h; Inert atmosphere;
2: carbonic acid dimethyl ester in tetrahydrofuran
T=20°C; 60 h; Inert atmosphere;
参考文献
Su, Jing; Tang, Haiqun; McKittrick, Brian A.
Tetrahedron Letters, 2011 , vol. 52, # 26 p. 3382 - 3385
反应条件
N,N,N',N',N'',N''-hexamethylphosphoric triamide; lithium diisopropyl amide in tetrahydrofuran
T=0°C; 1 h;
参考文献
Fischer, Derek; Theodorakis, Emmanuel A.
European Journal of Organic Chemistry, 2007 , # 25 p. 4193 - 4196
反应条件
diethyl ether; sodium hydride
参考文献
Lukes et al.
Journal of the American Chemical Society, 1952 , vol. 74, p. 1401,1403
