(5alpha)-3,14-二羟基-4,5-环氧吗喃-6-酮盐酸盐(1:1)合成路线 (共 1 条)
反应条件
1: noroxymorphone hydrochloride With sodium hydrogencarbonate in isobutyramide T=65 - 69°C; 0.166667 h; 2: bromomethyl-cyclopropane in isobutyramide T=69°C; 6.5 h; 3: With sodium hydroxide; water in isobutyramide pH=8.6 - 9;
参考文献
SANOFI-AVENTIS
Patent: US2008/214817 A1, 2008 ;
Location in patent: Page/Page column 1; 4 ;