LHRH (1-5) (FREE ACID)合成路线 （共 8 条）
反应条件
methoxybenzene; trifluoroacetic acid T=0°C; 3 h;
参考文献
Slomczynska, Urszula; Leplawy, Tomasz; Leplawy, Miroslaw, T.
Zeitschrift fuer Naturforschung, B: Chemical Sciences, 1992 , vol. 47, # 10 p. 1424 - 1430
反应条件
1: 78 percent / dioxane / 5 h / papain, dithioerythritol in phosphate buffer, pH 9 2: deprotection 3: 67 percent / methanol; H2O / 16 h / Ambient temperature; papain, dithioerythritol, pH 8 4: TFA, anisole / 3 h / 0 °C View Scheme
参考文献
Slomczynska, Urszula; Leplawy, Tomasz; Leplawy, Miroslaw, T.
Zeitschrift fuer Naturforschung, B: Chemical Sciences, 1992 , vol. 47, # 10 p. 1424 - 1430
反应条件
1: 67 percent / methanol; H2O / 16 h / Ambient temperature; papain, dithioerythritol, pH 8 2: TFA, anisole / 3 h / 0 °C View Scheme
参考文献
Slomczynska, Urszula; Leplawy, Tomasz; Leplawy, Miroslaw, T.
Zeitschrift fuer Naturforschung, B: Chemical Sciences, 1992 , vol. 47, # 10 p. 1424 - 1430
反应条件
1: deprotection 2: 67 percent / methanol; H2O / 16 h / Ambient temperature; papain, dithioerythritol, pH 8 3: TFA, anisole / 3 h / 0 °C View Scheme
参考文献
Slomczynska, Urszula; Leplawy, Tomasz; Leplawy, Miroslaw, T.
Zeitschrift fuer Naturforschung, B: Chemical Sciences, 1992 , vol. 47, # 10 p. 1424 - 1430
反应条件
1: 75 percent / CH2Cl2; H2O / 16 h / Ambient temperature; α-chymotrypsin 2: 67 percent / methanol; H2O / 16 h / Ambient temperature; papain, dithioerythritol, pH 8 3: TFA, anisole / 3 h / 0 °C View Scheme
参考文献
Slomczynska, Urszula; Leplawy, Tomasz; Leplawy, Miroslaw, T.
Zeitschrift fuer Naturforschung, B: Chemical Sciences, 1992 , vol. 47, # 10 p. 1424 - 1430
反应条件
1: 75 percent / CH2Cl2; H2O / 16 h / Ambient temperature; α-chymotrypsin 2: 67 percent / methanol; H2O / 16 h / Ambient temperature; papain, dithioerythritol, pH 8 3: TFA, anisole / 3 h / 0 °C View Scheme
参考文献
Slomczynska, Urszula; Leplawy, Tomasz; Leplawy, Miroslaw, T.
Zeitschrift fuer Naturforschung, B: Chemical Sciences, 1992 , vol. 47, # 10 p. 1424 - 1430
反应条件
1: 67 percent / methanol; H2O / 16 h / Ambient temperature; papain, dithioerythritol, pH 8 2: TFA, anisole / 3 h / 0 °C View Scheme
参考文献
Slomczynska, Urszula; Leplawy, Tomasz; Leplawy, Miroslaw, T.
Zeitschrift fuer Naturforschung, B: Chemical Sciences, 1992 , vol. 47, # 10 p. 1424 - 1430
反应条件
Yield given. Multistep reaction;
参考文献
Stetler-Stevenson, Mary Alice; Yang, Dai Chang; Lipkowski, Andrew; McCartney, Linda; Peterson, Darryl; Fluoret, George
Journal of Medicinal Chemistry, 1981 , vol. 24, # 6 p. 688 - 692
