5-氧代环戊-1-烯-1-庚酸合成路线 （共 67 条）
反应条件
hydrogenchloride in acetone
参考文献
American Cyanamid Company
Patent: US3932463 A1, 1976 ;
Title/Abstract Full Text Show Details
American Cyanamid Company
Patent: US3932472 A1, 1976 ;
反应条件
jones' reagent in acetone
T=5 - 15°C; 0.5 h;
参考文献
Caton, Michael P. L.; Darnbrough, Geoffrey; Parker, Trevor; Peart, Barry J.; Podmore, Michael L.; Threlfall, Terence L.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , p. 319 - 324
反应条件
chromic acid in acetone
参考文献
Savoia; Trombini; Umani-Ronchi
Journal of Organic Chemistry, 1982 , vol. 47, # 3 p. 564 - 566
反应条件
hydrogenchloride in water; acetone; Petroleum ether
参考文献
May and Baker Limited
Patent: US4171375 A1, 1979 ;
参考文献
Thakur, S. B.; Jadhav, K. S.; Bhattacharyya, S. C.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1986 , vol. 25, p. 675 - 683
参考文献
American Cyanamid Company
Patent: US3950406 A1, 1976 ;
参考文献
Rao, A.V. Rama; Deshpande, V.H.; Reddy, S. Pulla
Synthetic Communications, 1984 , vol. 14, # 5 p. 469 - 476
反应条件
1: 80 percent / tetrabutylammonium bromide, aq. NaOH / CH2Cl2
2: 1.) NaH / 1.) ether, -5-0 deg C, 10 min, 2.) ether, 10-15 deg C, 3 h
3: 1.) conc. HCl, 2.) PTS-acid / 1.) CH2Cl2-ether, 1 h, 2.) CH2Cl2, 0 deg C, 3 h
4: 1.) base, 2.) Jones reagent
View Scheme
参考文献
Rao, A.V. Rama; Deshpande, V.H.; Reddy, S. Pulla
Synthetic Communications, 1984 , vol. 14, # 5 p. 469 - 476
反应条件
1: 56 percent
2: p-toluenesulfonic acid / Heating
3: 1) CaCO3, Br2, 2) Li2CO3, / 1) CCl4, water, 0-5 deg C, 30 min, 2) DMF, 30 min, reflux
4: 95.8 percent / pyridine; ethanol / 22 h / Ambient temperature
5: 2N HCl / acetone / 5 h / Heating
View Scheme
参考文献
Bernady; Poletto; Nocera; et al.
Journal of Organic Chemistry, 1980 , vol. 45, # 23 p. 4702 - 4715
反应条件
1: LiBr, Li2CO3 / DMF, reflux, 0.5h
2: 95.8 percent / pyridine; ethanol / 22 h / Ambient temperature
3: 2N HCl / acetone / 5 h / Heating
View Scheme
参考文献
Bernady; Poletto; Nocera; et al.
Journal of Organic Chemistry, 1980 , vol. 45, # 23 p. 4702 - 4715
