(R)-(+)-2,2-二甲基-1,3-二氧戊环-4-羧酸甲酯合成路线

108865-84-51,3-二氧戊环-4-羧酸,2,2-二甲基-,甲酯→52373-72-5(R)-(+)-2,2-二甲基-1,3-二氧戊环-4-羧酸甲酯

参考文献

ALTUS BIOLOGICS INC.
Patent: WO2004/3001 A1, 2004 ;
Location in patent: Page 11-14 ;

108865-84-51,3-二氧戊环-4-羧酸,2,2-二甲基-,甲酯→102045-96-5(S)-2,2-二甲基-1,3-二氧戊环-4-甲酸+52373-72-5(R)-(+)-2,2-二甲基-1,3-二氧戊环-4-羧酸甲酯

参考文献

ALTUS BIOLOGICS INC.
Patent: WO2004/3001 A1, 2004 ;
Location in patent: Page 10 ;

67-56-1甲醇+15186-48-8(R)-(+)-2,2-二甲基-1,3-二氧戊环-4-甲醛→52373-72-5(R)-(+)-2,2-二甲基-1,3-二氧戊环-4-羧酸甲酯

参考文献

Ladame, Sylvain; Bardet, Michel; Perie, Jacques; Willson, Michele
Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 3 p. 773 - 783

186581-53-3重氮甲烷+114746-70-2(4R)-2,2-二甲基-1,3-二氧戊环-4-羧酸→52373-72-5(R)-(+)-2,2-二甲基-1,3-二氧戊环-4-羧酸甲酯

参考文献

Sodeoka, Mikiko; Sampe, Ruriko; Kagamizono, Terumi; Osada, Hiroyuki
Tetrahedron Letters, 1996 , vol. 37, # 48 p. 8775 - 8778

135547-99-8+74-88-4甲基碘→52373-72-5(R)-(+)-2,2-二甲基-1,3-二氧戊环-4-羧酸甲酯

参考文献

Maurya, Rakesh; Pittol, Carlos A.; Pryce, Robert J.; Roberts, Stanley M.; Thomas, Russell J.; Williams, Julian O.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1992 , # 13 p. 1617 - 1622

18289-89-9(R)-2,3-二羟基丙酸甲酯+67-64-1丙酮→52373-72-5(R)-(+)-2,2-二甲基-1,3-二氧戊环-4-羧酸甲酯

参考文献

Schoenecker, Bruno
Journal fuer Praktische Chemie (Leipzig), 1986 , vol. 328, # 5/6 p. 705 - 712

1067-52-3三正丁基甲氧基锡+15186-48-8(R)-(+)-2,2-二甲基-1,3-二氧戊环-4-甲醛→52373-72-5(R)-(+)-2,2-二甲基-1,3-二氧戊环-4-羧酸甲酯

参考文献

Carr, Kathryn; Greener, Neil A.; Mullah, Khairuzzaman, B.; Somerville, Fiona M.; Sutherland, James K.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1992 , # 15 p. 1975 - 1980

14028-61-6+74-88-4甲基碘→52373-72-5(R)-(+)-2,2-二甲基-1,3-二氧戊环-4-羧酸甲酯

参考文献

Ruholl, Heinrich; Schaefer, Hans J.
Synthesis, 1988 , # 1 p. 54 - 56

1707-77-3双丙酮-D-甘露糖醇→52373-72-5(R)-(+)-2,2-二甲基-1,3-二氧戊环-4-羧酸甲酯

参考文献

Ruholl, Heinrich; Schaefer, Hans J.
Synthesis, 1988 , # 1 p. 54 - 56

18289-89-9(R)-2,3-二羟基丙酸甲酯+116-11-02-甲氧基丙烯→52373-72-5(R)-(+)-2,2-二甲基-1,3-二氧戊环-4-羧酸甲酯

参考文献

Hirth; Walther
Helvetica Chimica Acta, 1985 , vol. 68, # 7 p. 1863 - 1871