(R)-(+)-2,2-二甲基-1,3-二氧戊环-4-羧酸甲酯合成路线 （共 20 条）
反应条件
sodium hydroxide; water; penicillin acylase T=10 - 20°C; pH=7.5; 3 - 20 h; Resolution of racemateAqueous phosphate buffer;
参考文献
ALTUS BIOLOGICS INC.
Patent: WO2004/3001 A1, 2004 ;
Location in patent: Page 11-14 ;
反应条件
sodium hydroxide; water; penicillin acylase T=20°C; pH=7.5; 2 h; Resolution of racemateAqueous phosphate buffer;
参考文献
ALTUS BIOLOGICS INC.
Patent: WO2004/3001 A1, 2004 ;
Location in patent: Page 10 ;
反应条件
bromine; sodium hydrogencarbonate in water T=20°C;
参考文献
Ladame, Sylvain; Bardet, Michel; Perie, Jacques; Willson, Michele
Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 3 p. 773 - 783
反应条件
in diethyl ether T=0°C;
参考文献
Sodeoka, Mikiko; Sampe, Ruriko; Kagamizono, Terumi; Osada, Hiroyuki
Tetrahedron Letters, 1996 , vol. 37, # 48 p. 8775 - 8778
反应条件
potassium fluoride in N,N-dimethyl-formamide 20 h; Ambient temperature;
参考文献
Maurya, Rakesh; Pittol, Carlos A.; Pryce, Robert J.; Roberts, Stanley M.; Thomas, Russell J.; Williams, Julian O.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1992 , # 13 p. 1617 - 1622
反应条件
toluene-4-sulfonic acid in dichloromethane 30 h; Heating;
参考文献
Schoenecker, Bruno
Journal fuer Praktische Chemie (Leipzig), 1986 , vol. 328, # 5/6 p. 705 - 712
反应条件
N-bromosuccinmide in tetrachloromethane 20 h; Ambient temperature;
参考文献
Carr, Kathryn; Greener, Neil A.; Mullah, Khairuzzaman, B.; Somerville, Fiona M.; Sutherland, James K.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1992 , # 15 p. 1975 - 1980
反应条件
N,N,N',N,-tetramethylethylenediamine in acetonitrile T=50°C; 5 h; Yield given;
参考文献
Ruholl, Heinrich; Schaefer, Hans J.
Synthesis, 1988 , # 1 p. 54 - 56
反应条件
1: sodium periodate, sodium bicarbonate / H2O / 1 h / 0 - 5 °C 2: 75.3 g / potassium hydroxide, potassium permanganate / H2O / 1.5 h / 20 - 23 °C 3: 38.4 g / dimethylformamide / 3 h View Scheme
参考文献
Ruholl, Heinrich; Schaefer, Hans J.
Synthesis, 1988 , # 1 p. 54 - 56
反应条件
toluene-4-sulfonic acid in acetone T=0°C; 0.5 h; Yield given;
参考文献
Hirth; Walther
Helvetica Chimica Acta, 1985 , vol. 68, # 7 p. 1863 - 1871
