6-甲氧基-3-甲基-9H-咔唑合成路线 （共 33 条）
反应条件
copper diacetate; palladium diacetate in acetic acid
T=117°C; 24 h;
参考文献
Forke, Ronny; Krahl, Micha P.; Krause, Tilo; Schlechtingen, Georg; Knoelker, Hans-Joachim
Synlett, 2007 , # 2 p. 268 - 272
反应条件
1,2-bis-(diphenylphosphino)ethane
T=150°C; Cadogan cyclization; 5 h; Neat (no solvent)Inert atmosphere; regioselective reaction;
参考文献
Peng, Haixia; Chen, Xuxing; Chen, Yanhong; He, Qian; Xie, Yuyuan; Yang, Chunhao
Tetrahedron, 2011 , vol. 67, # 32 p. 5725 - 5731
反应条件
1: With magnesium sulphate heptahydrate in methanol; dichloromethane
2: With sodium tetrahydroborate; palladium 10 on activated carbon
T=100°C; P=1551.49 - 2585.81 Torr; 0.0833333 h; Microwave irradiation;
参考文献
Chakraborty, Suchandra; Chattopadhyay, Gautam; Saha, Chandan
Journal of Heterocyclic Chemistry, 2013 , vol. 50, # 1 p. 91 - 98
反应条件
iodine in dimethyl sulfoxide
T=100°C; 7 h;
参考文献
Humne, Vivek; Dangat, Yuvraj; Vanka, Kumar; Lokhande, Pradeep
Organic and Biomolecular Chemistry, 2014 , vol. 12, # 27 p. 4832 - 4836
反应条件
water; potassium hydroxide in methanol
T=80°C; 18 h; Inert atmosphere;
参考文献
Kajiyama, Daichi; Inoue, Keisuke; Ishikawa, Yuichi; Nishiyama, Shigeru
Tetrahedron, 2010 , vol. 66, # 52 p. 9779 - 9784
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran
2.5 h; Reflux;
参考文献
Youn, So Won; Bihn, Joon Hyung; Kim, Byung Seok
Organic Letters, 2011 , vol. 13, # 14 p. 3738 - 3741
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
T=0 - 65°C; 1 h;
参考文献
Rasheed, Sk.; Rao, D. Nageswar; Reddy, K. Ranjith; Aravinda; Vishwakarma, Ram A.; Das, Parthasarathi
RSC Advances, 2014 , vol. 4, # 10 p. 4960 - 4969
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran; toluene
T=100°C; 4 h;
参考文献
Pirali, Tracey; Zhang, Fengzhi; Miller, Anna H.; Head, Jenna L.; McAusland, Donald; Greaney, Michael F.
Angewandte Chemie - International Edition, 2012 , vol. 51, # 4 p. 1006 - 1009
反应条件
potassium hydroxide; sodium hydroxide
T=230°C; 1 h;
参考文献
Bhattacharyya, P.; Jash, S. S.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1986 , vol. 25, p. 1056
反应条件
1: 97 percent / rac-BINAP; Cs2CO3 / Pd(OAc)2 / toluene / 144 h / 110 °C
2: 60 percent / Cu(OAc)2 / Pd(OAc)2 / acetic acid / 24 h / 117 °C
View Scheme
参考文献
Forke, Ronny; Krahl, Micha P.; Krause, Tilo; Schlechtingen, Georg; Knoelker, Hans-Joachim
Synlett, 2007 , # 2 p. 268 - 272
