3-乙氧基羰基-1-苯基戊烷-1,4-二酮合成路线 （共 29 条）
反应条件
[BMIm][HSO4]
T=150°C; Paal-Knorr pyrrole synthesis; 3 h;
参考文献
He, Yan-Hong; Wang, Gang-Qiang; Xu, Ke-Ling; Guan, Zhi
Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 2011 , vol. 66, # 2 p. 191 - 196
参考文献
Yokoyama,T.; Izui,N.
Bulletin of the Chemical Society of Japan, 1965 , vol. 38, p. 1501 - 1503
参考文献
Borsche; Menz
Chemische Berichte, 1908 , vol. 41, p. 195
反应条件
1: 60 percent / NH3 / acetic acid / 1 h / 80 °C / Heating
2: 95 percent / aq. NaOH / ethanol / 24 h / 50 °C
View Scheme
参考文献
Petruso, S.; Caronna, S.; Sferlazzo, M.; Sprio, V.
Journal of Heterocyclic Chemistry, 1990 , vol. 27, # 5 p. 1277 - 1280
反应条件
1: α-bromoacetophenone With sodium hydride in tetrahydrofuran; mineral oil
T=20°C; 0.5 h; Inert atmosphere;
2: ethyl acetoacetate in tetrahydrofuran
T=20°C; 4 h;
参考文献
Krizaj, David; Prestwich, Glenn D.; Barabas, Peter; Xu, Yong; Ryskamp, Daniel
Patent: US2013/303539 A1, 2013 ;
Location in patent: Paragraph 0131; 0132; 0133 ;
参考文献
Borsche; Fels
Chemische Berichte, 1906 , vol. 39, p. 1814
反应条件
1: ethyl acetoacetate With sodium hydride in tetrahydrofuran
T=0°C; 1.33333 h;
2: α-bromoacetophenone in tetrahydrofuran
T=0 - 20°C;
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED
Patent: WO2006/82952 A1, 2006 ;
Location in patent: Page/Page column 177 ;
参考文献
Mackay, Donald; Dao, Le H.; Dust, Julian M.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 2408 - 2416
反应条件
1.1: bromine
2.1: sodium ethanolate / 30 °C
2.2: 30 °C
View Scheme
参考文献
Vladimirova, Stanislava; Bijev, Atanas
Heterocyclic Communications, 2014 , vol. 20, # 2 p. 111 - 115
