1-甲基-5-硝基-1H-吲唑合成路线 （共 10 条）
反应条件
1: 5-nitro-1H-indazole With sodium hydride in N,N-dimethyl-formamide T=0°C; 1 h; 2: methyl iodide in N,N-dimethyl-formamide T=0 - 20°C; 18 h;
参考文献
MEMORY PHARMACEUTICALS CORPORATION; SCHUMACHER, Richard, A.; TEHIM, Ashok; XIE, Wenge
Patent: WO2010/24980 A1, 2010 ;
Location in patent: Page/Page column 114; 115 ;
反应条件
sodium hydride in N,N-dimethyl-formamide T=0 - 20°C; 1 h;
参考文献
Lee, Jeewoo; Tran, Phuong-Thao; Hoang, Van-Hai; Thorat, Shivaji A.; Kim, Sung Eun; Ann, Jihyae; Chang, Yu Jin; Nam, Dong Woo; Song, Hyundong; Mook-Jung, Inhee; Lee, Jiyoun
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 13 p. 3821 - 3830
反应条件
tert.-butylnitrite in tetrahydrofuran 1 h; Reflux;
参考文献
Liu, Han-Jun; Hung, Shiang-Fu; Chen, Chuan-Lin; Lin, Mei-Huey
Tetrahedron, 2013 , vol. 69, # 19 p. 3907 - 3912
反应条件
potassium hydroxide; water T=75°C; 0.5 h;
参考文献
Boyer, Gerard; Galy, Jean-Pierre; Faure, Robert; Elguero, Jose; Barbe, Jacques
Journal of Chemical Research, Miniprint, 1990 , # 11 p. 2601 - 2615
反应条件
sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate in tetrahydrofuran T=20°C; 3 h;
参考文献
Chakrabarty, Manas; Kundu, Taraknath; Arima, Shiho; Harigaya, Yoshihiro
Tetrahedron, 2008 , vol. 64, # 28 p. 6711 - 6723
反应条件
1: ethanol / |Reflux 2: tert.-butylnitrite / tetrahydrofuran / 1 h / |Reflux View Scheme
参考文献
Liu, Han-Jun; Hung, Shiang-Fu; Chen, Chuan-Lin; Lin, Mei-Huey
Tetrahedron, 2013 , vol. 69, # 19 p. 3907 - 3912
反应条件
potassium hydroxide in N,N-dimethyl-formamide
参考文献
Rahmani, Zeynab; Pordel, Mehdi; Davoodnia, Abolghasem
Bulletin of the Korean Chemical Society, 2014 , vol. 35, # 2 p. 551 - 556
反应条件
iron; ammonium chloride in ethanol; water T=80°C; 1 h;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2007/88478 A1, 2007 ;
Location in patent: Page/Page column 19 ;
反应条件
hydrogenchloride; tin(ll) chloride in methanol Heating;
参考文献
Miloudi, Abdellah; El Abed, Douniazed; Boyer, Gerard; Galy, Jean-Pierre
Heterocycles, 2006 , vol. 68, # 12 p. 2595 - 2605
反应条件
ammonia in ethanol
0.5 h; Irradiation;
参考文献
Bouchet, P.; Lazaro, R.; Benchidmi, M.; Elguero, J.
Tetrahedron, 1980 , vol. 36, p. 3523 - 3534
