(S)-(+)-2-氨基-2-苯基丁酸合成路线 （共 8 条）
反应条件
1: hydrogen chloride; ethanol View Scheme
参考文献
Sobotka; Holzman; Kahn
Journal of the American Chemical Society, 1932 , vol. 54, p. 4697,4699
参考文献
Sobotka
Patent: DE574657 , 1930 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 19, p. 1204
Full Text Show Details
Sobotka; Holzman; Kahn
Journal of the American Chemical Society, 1932 , vol. 54, p. 4697,4699
反应条件
amidase-containing Rhodococcus sp. AJ270; nitrile hydratase in phosphate buffer
T=30°C; pH=7.0; 48 h;
参考文献
Wang, Mei-Xiang; Lin, Shuan-Jun; Liu, Jun; Zheng, Qi-Yu
Advanced Synthesis and Catalysis, 2004 , vol. 346, # 4 p. 439 - 445
反应条件
chiral stationary phase including isopropyl-functionalized CF6 in methanol; acetic acid; triethylamine; acetonitrile
T=20°C; Purification / work up;
参考文献
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM; ARMSTRONG, Daniel, W.; PING, Sun; BREITBACH, Zachary, S.; WANG, Chunlei
Patent: WO2010/148191 A2, 2010 ;
Location in patent: Page/Page column 45-49; 61 ;
参考文献
Sobotka
Patent: DE574657 , 1930 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 19, p. 1204
Full Text Show Details
Sobotka; Holzman; Kahn
Journal of the American Chemical Society, 1932 , vol. 54, p. 4697,4699
反应条件
1: nBu4NI, KOH/K2CO3 melted / CH2Cl2 / 12 h / Ambient temperature
2: H2 / Pd(OH)2/C / methanol / 760 Torr
View Scheme
参考文献
O'Donnell, Martin J.; Fang, Zhiqiang; Ma, Xiaojun; Huffman, John C.
Heterocycles, 1997 , vol. 46, # 1 p. 617 - 630
反应条件
1: ueber das Chinin-Salz
2: aqueous sulfuric acid
View Scheme
参考文献
Sobotka; Holzman; Kahn
Journal of the American Chemical Society, 1932 , vol. 54, p. 4697,4699
反应条件
T=37°C; Mycobacterium neoaurum ATCC 25795, pH 8-8.5; Title compound not separated from byproducts;
参考文献
Kaptein; Boesten; Broxterman; Peters; Schoemaker; Kamphuis
Tetrahedron Asymmetry, 1993 , vol. 4, # 6 p. 1113 - 1116
