4-溴-1-羟基-2-萘乙酮合成路线 （共 14 条）
反应条件
1: pyridine / 0 - 20 °C
2: KOH / pyridine / 40 °C
3: sulfuric acid / acetic acid / Heating
View Scheme
参考文献
Springsteel, Mark F.; Galietta, Luis J. V.; Ma, Tonghui; By, Kolbot; Berger, Gideon O.; Yang, Hong; Dicus, Christopher W.; Choung, Wonken; Quan, Chao; Shelat, Anang A.; Guy, R. Kiplin; Verkman; Kurth, Mark J.; Nantz, Michael H.
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 18 p. 4113 - 4120
反应条件
1: pyridine / 0 - 20 °C
2: KOH / pyridine / 40 °C
3: sulfuric acid / acetic acid / Heating
View Scheme
参考文献
Springsteel, Mark F.; Galietta, Luis J. V.; Ma, Tonghui; By, Kolbot; Berger, Gideon O.; Yang, Hong; Dicus, Christopher W.; Choung, Wonken; Quan, Chao; Shelat, Anang A.; Guy, R. Kiplin; Verkman; Kurth, Mark J.; Nantz, Michael H.
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 18 p. 4113 - 4120
反应条件
1: pyridine / 0 - 20 °C
2: KOH / pyridine / 40 °C
3: sulfuric acid / acetic acid / Heating
View Scheme
参考文献
Springsteel, Mark F.; Galietta, Luis J. V.; Ma, Tonghui; By, Kolbot; Berger, Gideon O.; Yang, Hong; Dicus, Christopher W.; Choung, Wonken; Quan, Chao; Shelat, Anang A.; Guy, R. Kiplin; Verkman; Kurth, Mark J.; Nantz, Michael H.
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 18 p. 4113 - 4120
反应条件
pyridine
T=0 - 20°C; 2.08333 h;
参考文献
Springsteel, Mark F.; Galietta, Luis J. V.; Ma, Tonghui; By, Kolbot; Berger, Gideon O.; Yang, Hong; Dicus, Christopher W.; Choung, Wonken; Quan, Chao; Shelat, Anang A.; Guy, R. Kiplin; Verkman; Kurth, Mark J.; Nantz, Michael H.
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 18 p. 4113 - 4120
反应条件
copper(ll) bromide in 1,4-dioxane
3 h; Heating;
参考文献
Paranjape, M. V.; Wadokar, K. N.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1981 , vol. <B> 20, # 9 p. 808 - 809
反应条件
1: pyridine / 0 - 20 °C
2: KOH / pyridine / 40 °C
3: sulfuric acid / acetic acid / Heating
View Scheme
参考文献
Springsteel, Mark F.; Galietta, Luis J. V.; Ma, Tonghui; By, Kolbot; Berger, Gideon O.; Yang, Hong; Dicus, Christopher W.; Choung, Wonken; Quan, Chao; Shelat, Anang A.; Guy, R. Kiplin; Verkman; Kurth, Mark J.; Nantz, Michael H.
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 18 p. 4113 - 4120
反应条件
N-bromosuccinmide; dibenzoyl peroxide in benzene
4 h; RefluxInert atmosphere;
参考文献
Hassan, Zahid; Hussain, Munawar; Villinger, Alexander; Langer, Peter
Tetrahedron, 2012 , vol. 68, # 31 p. 6305 - 6313
参考文献
Torrey; Brewster
Journal of the American Chemical Society, 1909 , vol. 31, p. 1324
反应条件
bromine; acetic acid
参考文献
Fries; Schimmelschmidt
Chemische Berichte, 1925 , vol. 58, p. 2844
反应条件
Erwaermen des Reaktionsprodukts mit AlCl3;
参考文献
Chakravarti; Bagchi
Journal of the Indian Chemical Society, 1936 , vol. 13, p. 689,694
