4-(2-溴乙氧基)苯甲醛合成路线 （共 16 条）
反应条件
potassium carbonate in ethanol T=70°C; 20 h;
参考文献
EP2386555 A1, ;
Paragraph 0115 ;
反应条件
sodium hydroxide; potassium carbonate in N-methyl-acetamide; water
反应条件
1: 4-hydroxy-benzaldehyde With sodium hydroxide in ethanol; water 0.5 h; Reflux; 2: ethylene dibromide in ethanol; water 4.5 h; Reflux;
参考文献
Russian Chemical Bulletin, , vol. 60, # 7 p. 1495 - 1499
反应条件
potassium carbonate in N,N-dimethyl-formamide 68 h; Ambient temperature;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 35, # 6 p. 2394 - 2411
反应条件
1: alcohol 2: HCl; benzene; AlCl3 / unter allmaehlichem Erwaermen von 0gradC auf 45gradC und Zersetzung des Reaktionsproduktes durch Erhitzen mit verd. Salzsaeure View Scheme
参考文献
Justus Liebigs Annalen der Chemie, , vol. 357, p. 373
反应条件
hydrogenchloride; aluminium trichloride; benzene unter allmaehlichem Erwaermen von 0gradC auf 45gradC und Zersetzung des Reaktionsproduktes durch Erhitzen mit verd. Salzsaeure;
参考文献
Justus Liebigs Annalen der Chemie, , vol. 357, p. 373
反应条件
1.1: NaBH4 / methanol / 20 °C 2.1: tetrahydrofuran / Heating 3.1: HCl (gas) / tetrahydrofuran / 0 °C 3.2: SOCl2 / tetrahydrofuran / 50 °C View Scheme
参考文献
Ji, Qinggang; Gao, Jie; Wang, Junbo; Yang, Chunhao; Hui, Xin; Yan, Xueming; Wu, Xihan; Xie, Yuyuan; Wang, Ming-Wei
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 11 p. 2891 - 2893
反应条件
1: azacycloheptane With potassium carbonate in acetone 2 h; Inert atmosphereReflux; 2: 4-(2-bromoethoxy)benzaldehyde With potassium iodide in acetone Inert atmosphereReflux;
参考文献
Yadav, Yogesh; MacLean, Erin D.; Bhattacharyya, Annyt; Parmar, Virinder S.; Balzarini, Jan; Barden, Christopher J.; Too, Catherine K.L.; Jha, Amitabh
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 9 p. 3858 - 3866
反应条件
1: NaBH4 / methanol / 20 °C 2: tetrahydrofuran / Heating View Scheme
参考文献
Yadav, Yogesh; MacLean, Erin D.; Bhattacharyya, Annyt; Parmar, Virinder S.; Balzarini, Jan; Barden, Christopher J.; Too, Catherine K.L.; Jha, Amitabh
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 9 p. 3858 - 3866
反应条件
1.1: NaBH4 / methanol / 20 °C 2.1: tetrahydrofuran / Heating 3.1: HCl (gas) / tetrahydrofuran / 0 °C 3.2: SOCl2 / tetrahydrofuran / 50 °C View Scheme
参考文献
Ji, Qinggang; Gao, Jie; Wang, Junbo; Yang, Chunhao; Hui, Xin; Yan, Xueming; Wu, Xihan; Xie, Yuyuan; Wang, Ming-Wei
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 11 p. 2891 - 2893
