1,1'-(1,2-乙炔二基)二(4-氟苯)合成路线 （共 32 条）
参考文献
Hay; Allan S.; Paventi; Martino
Patent: US5233046 A1, 1993 ;
反应条件
iodine; dimethyl sulfoxide T=155°C; 14 h; Inert atmosphere;
参考文献
Jones, David J.; Purushothaman, Balaji; Ji, Shaomin; Holmes, Andrew B.; Wong, Wallace W. H.
Chemical Communications, 2012 , vol. 48, # 65 p. 8066 - 8068
反应条件
N-iodo-succinimide; trimethylsilylazide in 1,2-dichloro-ethane; acetonitrile T=20 - 70°C; 3 h;
参考文献
Okamoto, Noriko; Ishikura, Minoru; Yanada, Reiko
Organic Letters, 2013 , vol. 15, # 11 p. 2571 - 2573
反应条件
potassium carbonate in toluene
1.5 h; 1.) 140 deg C, 1.5 h, 2.) 160 deg C, 12 h;
参考文献
Paventi; Hay
Tetrahedron Letters, 1993 , vol. 34, # 6 p. 999 - 1002
反应条件
lead dioxide; trifluoroacetic acid in dichloromethane
T=0°C; 1.5 h;
参考文献
Vasil'ev; Rudenko
Russian Journal of Organic Chemistry, 2010 , vol. 46, # 9 p. 1282 - 1289
反应条件
copper(l) iodide; water; 1,8-diazabicyclo[5.4.0]undec-7-ene; bis-triphenylphosphine-palladium(II) chloride in benzene
T=60°C; Sonogashira reaction; 18 h;
参考文献
Mio, Matthew J; Kopel, Lucas C; Braun, Julia B; Gadzikwa, Tendai L; Hull, Kami L; Brisbois, Ronald G; Markworth, Christopher J; Grieco, Paul A
Organic letters, 2002 , vol. 4, # 19 p. 3199 - 3202
反应条件
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1,4-di(diphenylphosphino)-butane in dimethyl sulfoxide
T=30 - 80°C; 9 h; DarknessAerobic condition;
参考文献
Kim, Yong; Park, Ahbyeol; Park, Kyungho; Lee, Sunwoo
Tetrahedron Letters, 2011 , vol. 52, # 15 p. 1766 - 1769
反应条件
triethylamine; copper(l) iodide
Sonogashira coupling; 4 h; Heating;
参考文献
Gunay, Ahmet; Jones, William D.
Journal of the American Chemical Society, 2007 , vol. 129, # 28 p. 8729 - 8735
反应条件
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; water; 1,8-diazabicyclo[5.4.0]undec-7-ene in benzene
18 h; Inert atmosphereCooling with ice;
参考文献
Zhou, Feng; Han, Xiuling; Lu, Xiyan
Tetrahedron Letters, 2011 , vol. 52, # 36 p. 4681 - 4685
反应条件
potassium tert-butylate in N,N-dimethyl-formamide
T=75°C; 0.0333333 h;
参考文献
Paventi; Hay
Tetrahedron Letters, 1993 , vol. 34, # 6 p. 999 - 1002
