2,3,5,6-四氟-4-三氟甲基苯甲酸合成路线 （共 14 条）
反应条件
1: 7.09 g / SOCl2, DMF / 3 h / 80 - 110 °C 2: 3.14 g / KF / 16 h / 200 °C 3: 1.) SbF5, 2.) H2O / 1.) 130 deg C, 10 h View Scheme
参考文献
Karpov, V. M.; Panteleev, I. V.; Platonov, V. E.
Journal of Organic Chemistry USSR (English Translation), 1991 , vol. 27, p. 1932 - 1938
Zhurnal Organicheskoi Khimii, 1991 , vol. 27, p. 2183 - 2191
反应条件
1: 7.09 g / SOCl2, DMF / 3 h / 80 - 110 °C 2: 3.14 g / KF / 16 h / 200 °C View Scheme
参考文献
Karpov, V. M.; Panteleev, I. V.; Platonov, V. E.
Journal of Organic Chemistry USSR (English Translation), 1991 , vol. 27, p. 1932 - 1938
Zhurnal Organicheskoi Khimii, 1991 , vol. 27, p. 2183 - 2191
反应条件
1: 7.09 g / SOCl2, DMF / 3 h / 80 - 110 °C
2: 3.14 g / KF / 16 h / 200 °C
3: 1.) SbF5, 2.) H2O / 1.) 130 deg C, 10 h
4: SOCl2 / dimethylformamide / 3 h / 80 - 110 °C
5: KF / 16 h / 200 °C
View Scheme
参考文献
Karpov, V. M.; Panteleev, I. V.; Platonov, V. E.
Journal of Organic Chemistry USSR (English Translation), 1991 , vol. 27, p. 1932 - 1938
Zhurnal Organicheskoi Khimii, 1991 , vol. 27, p. 2183 - 2191
反应条件
1: With XeF2; Solkane® 365mfc; boron trifluoride
T=2 - 24°C;
2: With potassium permanganate in acetone
2 h;
参考文献
Bardin, Vadim V.; Frohn, Hermann-Josef
Journal of Fluorine Chemistry, 2013 , vol. 146, p. 98 - 104
反应条件
SbF5; trifluoroacetic acid
T=50°C; 11 h;
参考文献
Zonov, Yaroslav V.; Karpov, Victor M.; Platonov, Vyacheslav E.
Journal of Fluorine Chemistry, 2007 , vol. 128, # 9 p. 1058 - 1064
反应条件
1: N2H4*H2O / ethanol / Heating
2: aq. CuSO4
3: (i) nBuLi, (ii) /BRN= 1900390/, (iii) aq. HCl
View Scheme
参考文献
Tamborski,C.; Soloski,E.J.
Journal of Organic Chemistry, 1966 , vol. 31, p. 746 - 749
反应条件
sulfur(IV) fluoride; boron trifluoride
T=200°C;
参考文献
Camaggi,G.; Gozzo,F.
Journal of the Chemical Society [Section] C: Organic, 1969 , p. 489 - 500
反应条件
magnesium anthracene
1.) THF, 0 deg C, 2.) THF, 0 deg C, 40 min; 0 deg C to r.t.; Yield given. Multistep reaction;
参考文献
Beck, Christopher M.; Park, You-Jung; Crabtree, Robert H.
Chemical Communications, 1998 , # 6 p. 693 - 694
反应条件
magnesium anthracene
1.) THF, -41 deg C, 2.) THF, -41 deg C, 40 min; -41 deg C to r.t.; Yield given. Multistep reaction;
参考文献
Beck, Christopher M.; Park, You-Jung; Crabtree, Robert H.
Chemical Communications, 1998 , # 6 p. 693 - 694
反应条件
1: aq. CuSO4
2: (i) nBuLi, (ii) /BRN= 1900390/, (iii) aq. HCl
View Scheme
参考文献
Tamborski,C.; Soloski,E.J.
Journal of Organic Chemistry, 1966 , vol. 31, p. 746 - 749
