外消旋-(S*)-2-(乙酰氨基)-3-甲基丁酸甲酯合成路线 （共 15 条）
反应条件
1: (i) tBuOCl, (ii) /BRN= 3592982/ 2: aq. H2SO4 / diethyl ether; tetrahydrofuran / Heating View Scheme
参考文献
Poisel,H.
Chemische Berichte, 1978 , vol. 111, p. 3136 - 3139
反应条件
Acylase I on Eupergit C; water T=25°C; 27 h;
参考文献
Liljeblad, Arto; Aksela, Reijo; Kanerva, Liisa T.
Tetrahedron Asymmetry, 2001 , vol. 12, # 14 p. 2059 - 2066
反应条件
rice bran lipase; sodium chloride T=30°C; pH=7.5; Title compound not separated from byproducts;
参考文献
Fadnavis; Jadhav, Vasudev
Tetrahedron Asymmetry, 1997 , vol. 8, # 14 p. 2361 - 2366
参考文献
Bhalerao; Rao; Fadnavis
Synthetic Communications, 1994 , vol. 24, # 15 p. 2109 - 2118
反应条件
Acylase I on Eupergit C; water T=25°C; 27 h;
参考文献
Liljeblad, Arto; Aksela, Reijo; Kanerva, Liisa T.
Tetrahedron Asymmetry, 2001 , vol. 12, # 14 p. 2059 - 2066
反应条件
4-methyl-morpholine in dichloromethane
T=20°C; 12 h;
参考文献
Malavasic, Crt; Stanovnik, Branko; Wagger, Jernej; Svete, Jurij
Tetrahedron Asymmetry, 2011 , vol. 22, # 12 p. 1364 - 1371
反应条件
hydrogen; iridium in dichloromethane
T=19.9°C; 0.00416667 h;
参考文献
Cabeza, Javier A.; Cativiela, Carlos; de Villegas, Maria D. Diaz; Oro, Luis A.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988 , p. 1881 - 1884
反应条件
triethylamine in tetrahydrofuran
Heating; Yield given;
参考文献
Evans, Emily F.; Lewis, Norman J.; Kapfer, Isabelle; Macdonald, Gregor; Taylor, Richard J. K.
Synthetic Communications, 1997 , vol. 27, # 11 p. 1819 - 1825
反应条件
1: SOCl2
2: 2.462 g / Et3N / CH2Cl2
View Scheme
参考文献
Liljeblad, Arto; Aksela, Reijo; Kanerva, Liisa T.
Tetrahedron Asymmetry, 2001 , vol. 12, # 14 p. 2059 - 2066
反应条件
1: H2, triethylamine / <Ph(NBD)2>ClO4, (2S,4S)-MOD-BPPM / ethanol / 45 h / 50 °C / 15200 Torr
2: diethyl ether
View Scheme
参考文献
Takahashi, Hisashi; Achiwa, Kazuo
Chemistry Letters, 1989 , p. 305 - 308
