2-苯基-1H-咪唑-4,5-二甲酸二甲酯合成路线 （共 4 条）
反应条件
1: With sulfuric acid
20 h; Heating / reflux;
2: With sodium hydroxide in methanol
T=0°C; pH=~ 7;
参考文献
BRISTOL-MYERS SQUIBB COMPANY
Patent: WO2005/42537 A1, 2005 ;
Location in patent: Page/Page column 73 ;
WO 2005/042537 A1
反应条件
sulfuric acid
50 h; Reflux;
参考文献
Sivek, Roman; Pytela, Oldrich; Bures, Filip
Journal of Heterocyclic Chemistry, 2008 , vol. 45, # 6 p. 1621 - 1627
反应条件
1: 2.) HCl / 1.) benzene, reflux, 38 h.; 2.) ether, 3 h.
2: 24 percent / petroleum ether / 7 h / Irradiation
View Scheme
参考文献
Casey, Michael; Moody, Christopher J.; Rees, Charles W.; Young, Richard G.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 741 - 746
反应条件
in Petroleum ether
7 h; Irradiation;
参考文献
Casey, Michael; Moody, Christopher J.; Rees, Charles W.; Young, Richard G.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 741 - 746
