2,3,5,6-四氟-4-巯基苯甲酸合成路线 （共 13 条）
反应条件
1: 978 mg / 30percent H2O2, AcOH / 2 h / 70 °C 2: SOCl2, DMF / 6 h / Heating View Scheme
参考文献
Fielding, H. C.; Shirley, I. M.
Journal of Fluorine Chemistry, 1992 , vol. 59, # 1 p. 15 - 31
反应条件
hydrogenchloride; sodium hydroxide; NaSH; dihydrogen peroxide in water; acetic acid
参考文献
Imperial Chemical Industries PLC
Patent: US5169983 A1, 1992 ;
反应条件
dihydrogen peroxide; acetic acid T=70°C; 2 h;
参考文献
Fielding, H. C.; Shirley, I. M.
Journal of Fluorine Chemistry, 1992 , vol. 59, # 1 p. 15 - 31
反应条件
1: 978 mg / 30percent H2O2, AcOH / 2 h / 70 °C
2: SOCl2, DMF / 6 h / Heating
3: NaF, Ph4PBr / various solvent(s) / 10 h / 155 °C
4: diethyl ether
View Scheme
参考文献
Fielding, H. C.; Shirley, I. M.
Journal of Fluorine Chemistry, 1992 , vol. 59, # 1 p. 15 - 31
反应条件
in diethyl ether; hexane
at -70°C after acidification with 6 N HCl;
参考文献
Tamborski,C.; Soloski,E.J.
Journal of Organic Chemistry, 1966 , vol. 31, p. 746 - 749
反应条件
by lithiation, followed by react. with sulfur at -60°C;
参考文献
Tamborski, C.; Soloski, E. J.
Journal of Organic Chemistry, 1966 , vol. 31, p. 743 - 745
反应条件
sodium hydroxide; sodium hydrogensulfide
T=70°C; 2 h;
参考文献
Fielding, H. C.; Shirley, I. M.
Journal of Fluorine Chemistry, 1992 , vol. 59, # 1 p. 15 - 31
反应条件
1: pyridine; ethylene glycol
2: CO2; C4H9Li
View Scheme
参考文献
Gmelin Handbook: F: PerFHalOrg.1, 1.1.6.2, page 97 - 116
反应条件
C4H9Li; CO2
hydrolysis;
参考文献
Brooke,G.M.; Quasem,M.A.
Journal of the Chemical Society [Section] C: Organic, 1967 , p. 865 - 869
反应条件
(i) nBuLi, (ii) /BRN= 1900390/, (iii) aq. HCl; Multistep reaction;
参考文献
Tamborski,C.; Soloski,E.J.
Journal of Organic Chemistry, 1966 , vol. 31, p. 746 - 749
