potassium carbonate in methanol T=0°C; 4 h;

alcohol dehydrogenase Evo-200; nicotinamide adenine dinucleotide; isopropyl alcohol; magnesium chloride in aq. phosphate buffer T=30°C; pH=7; 48 h; Inert atmosphereSchlenk techniqueEnzymatic reaction; Catalytic behavior; Reagent/catalystTime; enantioselective reaction;

Amano PS Lipase in hexane; benzene T=50°C; 72 h;

1: Dess-Martin periodane / dichloromethane / 20 °C / |Inert atmosphere; |Schlenk technique 2: nicotinamide adenine dinucleotide; magnesium chloride; alcohol dehydrogenase Evo-200; isopropyl alcohol / aq. phosphate buffer / 48 h / 30 °C / pH 7 / |Inert atmosphere; |Schlenk technique; |Enzymatic reaction View Scheme

1.1: n-butyllithium / diethyl ether; hexane / 0.83 h / -78 °C / |Inert atmosphere; |Schlenk technique 1.2: 3 h / -78 - 20 °C / |Inert atmosphere; |Schlenk technique 2.1: Dess-Martin periodane / dichloromethane / 20 °C / |Inert atmosphere; |Schlenk technique 3.1: nicotinamide adenine dinucleotide; magnesium chloride; alcohol dehydrogenase Evo-200; isopropyl alcohol / aq. phosphate buffer / 48 h / 30 °C / pH 7 / |Inert atmosphere; |Schlenk technique; |Enzymatic reaction View Scheme

Burkholderia cepacia lipase immobilized on ceramic particles T=20°C; 18 h; Title compound not separated from byproducts;