(S)-(-)-α-羟基-γ-丁内酯合成路线 （共 23 条）
反应条件
1: With trifluoroacetic anhydride T=25°C; 2 h; 2: With methanol 12 h; 3: With borane-THF more than 3 stages;
参考文献
Schering, AG
Patent: US7001916 B1, 2006 ;
Location in patent: Page/Page column 70 ;
反应条件
1: With diborane in tetrahydrofuran Inert atmosphere; 2: With toluene-4-sulfonic acid in benzene Inert atmosphere;
参考文献
Liu, Hongqiang; El-Salfiti, Mohamed; Chai, David I.; Auffret, Jeremy; Lautens, Mark
Organic Letters, 2012 , vol. 14, # 14 p. 3648 - 3651
反应条件
toluene-4-sulfonic acid in dichloromethane T=25°C; 1 h;
参考文献
Vidari; Lanfranchi; Sartori; Serra
Tetrahedron Asymmetry, 1995 , vol. 6, # 12 p. 2977 - 2990
反应条件
water 2 h; Heating / reflux;
参考文献
NEUROSEARCH A/S
Patent: WO2004/18466 A2, 2004 ;
Location in patent: Page 9; 7 ;
反应条件
boric acid trimethyl ester; dimethylsulfide borane complex in tetrahydrofuran T=20°C; Reduction; 24 h;
参考文献
Schinzer, Dieter; Bauer, Armin; Schieber, Jennifer
Chemistry - A European Journal, 1999 , vol. 5, # 9 p. 2492 - 2500
反应条件
hydrogen in dimethyl-ether T=56 - 110°C; P=120012 Torr; 0.5 - 2 h; Product distribution / selectivity;
参考文献
AVECIA LIMITED
Patent: WO2005/23737 A1, 2005 ;
Location in patent: Page/Page column 10-12 ;
反应条件
dimethylsulfide borane complex in tetrahydrofuran
参考文献
Mendlik, Matthew T.; Cottard, Muriel; Rein, Tobias; Helquist, Paul
Tetrahedron Letters, 1997 , vol. 38, # 36 p. 6375 - 6378
反应条件
in tetrahydrofuran; methanol; toluene; trifluoroacetic anhydride
参考文献
Buchmann, Bernd; Klar, Ulrich; Skuballa, Werner; Schwede, Wolfgang; Lichtner, Rosemarie; Hoffmann, Jens
Patent: US2004/58969 A1, 2004 ;
反应条件
trifluoroacetic acid in tetrahydrofuran; methanol; water; toluene
参考文献
American Cyanamid Company
Patent: US4937235 A1, 1990 ;
反应条件
toluene-4-sulfonic acid in dichloromethane T=20°C;
参考文献
Suzuki, Kenta; Takayama, Hiromitsu
Organic Letters, 2006 , vol. 8, # 20 p. 4605 - 4608
