1-(2-噻吩基羰基)哌嗪 CF3COOH合成路线 （共 8 条）
反应条件
trifluoroacetic acid in dichloromethane
T=20°C; 3 h;
参考文献
AVANIR PHARMACEUTICALS
Patent: WO2004/74218 A2, 2004 ;
Location in patent: Page 89 ;
反应条件
1: thiophene-2-carboxylic acid With N-bromosuccinmide; triphenylphosphine in dichloromethane
T=0 - 5°C; 0.25 h;
2: piperazine With pyridine in dichloromethane
T=20°C; 0.583333 h;
参考文献
Bandgar; Bettigeri
Synthetic Communications, 2004 , vol. 34, # 16 p. 2917 - 2924
反应条件
acetic acid
T=60°C; 0.0666667 h; SonicationIrradiation;
参考文献
Maurya, Ram Awatar; Hoang, Phan Huy; Kim, Dong-Pyo
Lab on a Chip - Miniaturisation for Chemistry and Biology, 2012 , vol. 12, # 1 p. 65 - 68
反应条件
1,1,1,3,3,3-hexamethyl-disilazane
T=110°C; 24 h; Yields of byproduct given;
参考文献
Chou, Wen-Chih; Chou, Ming-Chen; Lu, Yann-Yu; Chen, Shyh-Fong
Tetrahedron Letters, 1999 , vol. 40, # 17 p. 3419 - 3422
参考文献
Chou, Wen-Chih; Tan, Chang-Wei; Chen, Shyh-Fong; Ku, Hao
Journal of Organic Chemistry, 1998 , vol. 63, # 26 p. 10015 - 10017
反应条件
T=110 - 150°C; 30 h;
参考文献
da Silva, Joaquim Fernando Mendes; Walters, Marcus; Al-Damluji, Saad; Ganellin, C. Robin
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 15 p. 7254 - 7263
反应条件
1: triethylamine / dichloromethane / 20 °C
2: hydrogenchloride; water / dichloromethane / 20 °C
View Scheme
参考文献
Zulli, Allison L.; Aimone, Lisa D.; Mathiasen, Joanne R.; Gruner, John A.; Raddatz, Rita; Bacon, Edward R.; Hudkins, Robert L.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 8 p. 2807 - 2810
反应条件
in water; dimethyl sulfoxide
T=25°C; KineticsMechanism; Concentration;
参考文献
Pyun, Sang Yong; Cho, Bong Rae
Bulletin of the Korean Chemical Society, 2013 , vol. 34, # 7 p. 2036 - 2040
