4-甲氧基-2,6-吡啶二甲酸合成路线 （共 12 条）
反应条件
1: thionyl chloride / dimethylformamide
2: 42.9 percent / benzene / 48 h / 50 °C
View Scheme
参考文献
Bradshaw, J. S.; Maas, G. E.; Lamb, J. D.; Izatt, R. M.; Christensen J. J.
Journal of the American Chemical Society, 1980 , vol. 102, # 2 p. 467 - 474
反应条件
sodium hydroxide in 1,4-dioxane; methanol
T=20°C; 4 h;
参考文献
Haldar, Debasish; Jiang, Hua; Leger, Jean-Michel; Huc, Ivan
Tetrahedron, 2007 , vol. 63, # 27 p. 6322 - 6330
反应条件
1: SOCl2 / dimethylformamide / 48 h / Heating
2: MeONa / 2 h / Heating
3: H2O; K2CO3 / methanol / 18 h / 20 °C
View Scheme
参考文献
Tse, Man Kin; Bhor, Santosh; Klawonn, Markus; Anilkumar, Gopinathan; Jiao, Haijun; Doebler, Christian; Spannenberg, Anke; Magerlein, Wolfgang; Hugl, Herbert; Beller, Matthias
Chemistry - A European Journal, 2006 , vol. 12, # 7 p. 1855 - 1874
反应条件
1: thionyl chloride, dimethylformamide / Heating
4: hydrolysis
View Scheme
参考文献
Bradshaw, J. S.; Maas, G. E.; Lamb, J. D.; Izatt, R. M.; Christensen J. J.
Journal of the American Chemical Society, 1980 , vol. 102, # 2 p. 467 - 474
反应条件
1: 98 percent / methanol / 2 h / Heating
2: aq. K2CO3 / methanol / 18 h / Ambient temperature
View Scheme
参考文献
Parlow, John J.
Journal of Heterocyclic Chemistry, 1998 , vol. 35, # 6 p. 1493 - 1499
反应条件
1: methanol; toluene / 0.5 h / 20 °C
2: water; sodium hydroxide / methanol / 1 h / 20 °C
View Scheme
参考文献
Mueller, Sebastian; Sanders, Deborah A.; Di Antonio, Marco; Matsis, Stephanos; Riou, Jean-Francois; Rodriguez, Raphael; Balasubramanian, Shankar
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 32 p. 6537 - 6546
反应条件
1: MeONa / 2 h / Heating
2: H2O; K2CO3 / methanol / 18 h / 20 °C
View Scheme
参考文献
Tse, Man Kin; Bhor, Santosh; Klawonn, Markus; Anilkumar, Gopinathan; Jiao, Haijun; Doebler, Christian; Spannenberg, Anke; Magerlein, Wolfgang; Hugl, Herbert; Beller, Matthias
Chemistry - A European Journal, 2006 , vol. 12, # 7 p. 1855 - 1874
反应条件
potassium permanganate
Inert atmosphere;
参考文献
Zohuri, Gholam Hossein; Seyedi, Seyed Mohammad; Sandaroos, Reza; Damavandi, Saman; Mohammadi, Ali
Catalysis Letters, 2010 , vol. 140, # 3-4 p. 160 - 166
反应条件
1: dihydrogen peroxide; acetic acid / water / 27 h / 70 °C / Inert atmosphere
2: sulfuric acid; nitric acid / 7 h / 128 - 130 °C / Inert atmosphere
3: methanol / 5 h / Reflux; Inert atmosphere
4: triphenylphosphine / 1,2-bis-(2-hydroxyethoxy)-ethane / 1 h / 200 °C / Inert atmosphere
5: potassium permanganate / Inert atmosphere
View Scheme
参考文献
Zohuri, Gholam Hossein; Seyedi, Seyed Mohammad; Sandaroos, Reza; Damavandi, Saman; Mohammadi, Ali
Catalysis Letters, 2010 , vol. 140, # 3-4 p. 160 - 166
反应条件
1: sulfuric acid; nitric acid / 7 h / 128 - 130 °C / Inert atmosphere
2: methanol / 5 h / Reflux; Inert atmosphere
3: triphenylphosphine / 1,2-bis-(2-hydroxyethoxy)-ethane / 1 h / 200 °C / Inert atmosphere
4: potassium permanganate / Inert atmosphere
View Scheme
参考文献
Zohuri, Gholam Hossein; Seyedi, Seyed Mohammad; Sandaroos, Reza; Damavandi, Saman; Mohammadi, Ali
Catalysis Letters, 2010 , vol. 140, # 3-4 p. 160 - 166
