2-氨基-5-氯苯甲酸甲酯合成路线 （共 39 条）
参考文献
Darby,A.C. et al.
Journal of the Chemical Society [Section] C: Organic, 1971 , p. 1757 - 1761
反应条件
aluminium trichloride
1.) 25 deg C, 45 min, 2.) diethyl ether, 3 h, room temp.; Yield given. Multistep reaction;
参考文献
Acharya, Baman Prasad; Rao, Y. Ramachandra
Journal of Chemical Research, Miniprint, 1987 , # 4 p. 1001 - 1035
反应条件
1: bromoacetic acid N-hydroxysuccinimide ester; triphenylphosphino resin in toluene
16 h;
2: With triethylamine in dichloromethane
16 h;
3: 1-amino-4-chlorobenzene-2-carboxylic acid methyl ester in 1,4-dioxane
T=180°C; 0.25 h; microwave irradiation; Further stages.;
参考文献
Henkel, Bernd
Synlett, 2008 , # 3 p. 355 - 358
反应条件
acetic acid
4 h; Heating;
参考文献
Ilyn, Alexey P.; Trifilenkov, Andrey S.; Kuzovkova, Julia A.; Kutepov, Sergey A.; Nikitin, Alexandre V.; Ivachtchenko, Alexandre V.
Journal of Organic Chemistry, 2005 , vol. 70, # 4 p. 1478 - 1481
反应条件
1: 90 percent / acetic acid / 4 h / Heating
2: 77 percent / POCl3 / 5 h / 50 - 60 °C
View Scheme
参考文献
Massa; Corelli; Pantaleoni; Palumbo
Farmaco, Edizione Scientifica, 1983 , vol. 38, # 11 p. 893 - 903
反应条件
1: 65 percent / acetic acid / 0.5 h / Heating
2: 84 percent / POCl3 / 3 h / Ambient temperature
3: 80 percent / NaBH4 / 2-methyl-propan-2-ol; diethyl ether / 2 h / Heating
View Scheme
参考文献
Massa; Corelli; Pantaleoni; Palumbo
Farmaco, Edizione Scientifica, 1983 , vol. 38, # 11 p. 893 - 903
反应条件
1: 90.2 percent / 72 h / Heating
2: 65.9 percent / aq. ethanol / 20 h / Heating
View Scheme
参考文献
Leiby, Robert W.
Journal of Organic Chemistry, 1985 , vol. 50, # 16 p. 2926 - 2929
反应条件
(i) ClCH2CH2Cl, (ii) piperidine, dioxane; Multistep reaction;
参考文献
Kampe,K.-D.
Synthesis, 1976 , p. 469 - 471
反应条件
(i) ClCH2CH2Cl, (ii) piperidine, dioxane; Multistep reaction;
参考文献
Kampe,K.-D.
Synthesis, 1976 , p. 469 - 471
