trimethylsilyl trifluoromethanesulfonate in tetrahydrofuran 1 h; Ambient temperature; Yields of byproduct given;

in toluene

1: 70 percent / p-chloranil / 2-methyl-propan-2-ol / Heating 2: 64 percent / TMSOTf / tetrahydrofuran / 1 h / Ambient temperature View Scheme

1: 98 percent / trimethyl orthoformate, p-toluenesulfonic acid / methanol / 3 h / 50 °C 2: H2, triphenylphosphine, rhodium acetate dimer / ethyl acetate / 20 h / 80 °C / 9000.7 Torr 3: 100 percent / N-methylmorpholine N-oxide (NMO), RuCl2(Ph3P)3 / dimethylformamide / 0.17 h 4: 97 percent / 6 N HCl / tetrahydrofuran / 0.5 h 5: 70 percent / p-chloranil / 2-methyl-propan-2-ol / Heating 6: 64 percent / TMSOTf / tetrahydrofuran / 1 h / Ambient temperature View Scheme

1: H2, triphenylphosphine, rhodium acetate dimer / ethyl acetate / 20 h / 80 °C / 9000.7 Torr 2: 100 percent / N-methylmorpholine N-oxide (NMO), RuCl2(Ph3P)3 / dimethylformamide / 0.17 h 3: 97 percent / 6 N HCl / tetrahydrofuran / 0.5 h 4: 70 percent / p-chloranil / 2-methyl-propan-2-ol / Heating 5: 64 percent / TMSOTf / tetrahydrofuran / 1 h / Ambient temperature View Scheme

1: 100 percent / N-methylmorpholine N-oxide (NMO), RuCl2(Ph3P)3 / dimethylformamide / 0.17 h 2: 97 percent / 6 N HCl / tetrahydrofuran / 0.5 h 3: 70 percent / p-chloranil / 2-methyl-propan-2-ol / Heating 4: 64 percent / TMSOTf / tetrahydrofuran / 1 h / Ambient temperature View Scheme

1: 97 percent / 6 N HCl / tetrahydrofuran / 0.5 h 2: 70 percent / p-chloranil / 2-methyl-propan-2-ol / Heating 3: 64 percent / TMSOTf / tetrahydrofuran / 1 h / Ambient temperature View Scheme

in water T=20°C; Michael addition; 2 h;

暂无反应条件数据

1.1: sodium methylate / methanol / 0.67 h / 20 °C 1.2: pH 7 2.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 0.5 h / 20 °C View Scheme