1: diethyl ether; hexane / -78 - 20 °C 2: chloro-trimethyl-silane / dichloromethane / 2 h / 20 °C 3: palladium 10 on activated carbon; hydrogen / ethanol / 2 h / 20 °C 4: 1,10-phenanthroline; oxygen; copper(l) chloride; 2-hydroxy-1,3-isoindolinedione / acetonitrile; benzene / 24 h / 50 °C View Scheme

1.1: diethyl ether / -78 - 20 °C 2.1: dihydrogen peroxide; sulfuric acid / tetrahydrofuran; water / 8 h / 0 - 60 °C 3.1: copper diacetate; 1,10-phenanthroline; triethylamine; oxygen / toluene; acetonitrile / 20 °C 3.2: 20 °C 4.1: diethyl ether; hexane / -78 - 20 °C 5.1: chloro-trimethyl-silane / dichloromethane / 2 h / 20 °C 6.1: palladium 10 on activated carbon; hydrogen / ethanol / 2 h / 20 °C 7.1: 1,10-phenanthroline; oxygen; copper(l) chloride; 2-hydroxy-1,3-isoindolinedione / acetonitrile; benzene / 24 h / 50 °C View Scheme

1.1: diethyl ether / -78 - 20 °C 2.1: dihydrogen peroxide; sulfuric acid / tetrahydrofuran; water / 8 h / 0 - 60 °C 3.1: copper diacetate; 1,10-phenanthroline; triethylamine; oxygen / toluene; acetonitrile / 20 °C 3.2: 20 °C 4.1: diethyl ether; hexane / -78 - 20 °C 5.1: chloro-trimethyl-silane / dichloromethane / 2 h / 20 °C 6.1: palladium 10 on activated carbon; hydrogen / ethanol / 2 h / 20 °C 7.1: 1,10-phenanthroline; oxygen; copper(l) chloride; 2-hydroxy-1,3-isoindolinedione / acetonitrile; benzene / 24 h / 50 °C View Scheme

1.1: tetrahydrofuran 1.2: 48 h / |Reflux 2.1: diethyl ether / -78 - 20 °C 3.1: dihydrogen peroxide; sulfuric acid / tetrahydrofuran; water / 8 h / 0 - 60 °C 4.1: copper diacetate; 1,10-phenanthroline; triethylamine; oxygen / toluene; acetonitrile / 20 °C 4.2: 20 °C 5.1: diethyl ether; hexane / -78 - 20 °C 6.1: chloro-trimethyl-silane / dichloromethane / 2 h / 20 °C 7.1: palladium 10 on activated carbon; hydrogen / ethanol / 2 h / 20 °C 8.1: 1,10-phenanthroline; oxygen; copper(l) chloride; 2-hydroxy-1,3-isoindolinedione / acetonitrile; benzene / 24 h / 50 °C View Scheme

1.1: copper diacetate; 1,10-phenanthroline; triethylamine; oxygen / toluene; acetonitrile / 20 °C 1.2: 20 °C 2.1: diethyl ether; hexane / -78 - 20 °C 3.1: chloro-trimethyl-silane / dichloromethane / 2 h / 20 °C 4.1: palladium 10 on activated carbon; hydrogen / ethanol / 2 h / 20 °C 5.1: 1,10-phenanthroline; oxygen; copper(l) chloride; 2-hydroxy-1,3-isoindolinedione / acetonitrile; benzene / 24 h / 50 °C View Scheme

1.1: copper diacetate; 1,10-phenanthroline; triethylamine; oxygen / toluene; acetonitrile / 20 °C 1.2: 20 °C 2.1: diethyl ether; hexane / -78 - 20 °C 3.1: chloro-trimethyl-silane / dichloromethane / 2 h / 20 °C 4.1: palladium 10 on activated carbon; hydrogen / ethanol / 2 h / 20 °C 5.1: 1,10-phenanthroline; oxygen; copper(l) chloride; 2-hydroxy-1,3-isoindolinedione / acetonitrile; benzene / 24 h / 50 °C View Scheme

1.1: copper diacetate; 1,10-phenanthroline; triethylamine; oxygen / toluene; acetonitrile / 20 °C 1.2: 20 °C 2.1: diethyl ether; hexane / -78 - 20 °C 3.1: chloro-trimethyl-silane / dichloromethane / 2 h / 20 °C 4.1: palladium 10 on activated carbon; hydrogen / ethanol / 2 h / 20 °C 5.1: 1,10-phenanthroline; oxygen; copper(l) chloride; 2-hydroxy-1,3-isoindolinedione / acetonitrile; benzene / 24 h / 50 °C View Scheme

ethanol; palladium Hydrogenation;

in diethyl ether