2-(3,4-二羟基苯基)-3,5,7-三羟基-6-甲氧基-4-苯并吡喃酮合成路线 （共 16 条）
反应条件
pyridine hydrochloride
参考文献
Saleh, Nabiel A. M.; El-Negoumy, Sabry I.; Abd-Alla, Mohamed F.; Abou-Zaid, Mamdouh M.; Dellamonica, G.; Chopin, J.
Phytochemistry (Elsevier), 1985 , vol. 24, # 1 p. 201 - 203
反应条件
potassium carbonate in acetone
T=20°C; 96 h;
参考文献
Faizi, Shaheen; Siddiqi, Humaira; Naz, Aneela; Bano, Samina; Lubna
Helvetica Chimica Acta, 2010 , vol. 93, # 3 p. 466 - 481
反应条件
hydrogen; palladium on activated charcoal in methanol; ethyl acetate
Ambient temperature;
参考文献
Horie, Tokunaru; Shibata, Kenichi; Yamashita, Kazuyo; Kawamura, Yasuhiko; Tsukayama, Masao
Chemical and Pharmaceutical Bulletin, 1997 , vol. 45, # 3 p. 446 - 451
反应条件
1: 100 percent / conc. HCl, acetic acid / 1 h / Ambient temperature
2: 83 percent / K2CO3, KI / acetone; dimethylformamide / Heating
3: 75 percent / AlBr3, NaI / acetonitrile / 0.25 h / 0 °C
4: pyridine / 2 h / 70 - 80 °C
5: KOH / pyridine / 80 °C
6: 97 percent / conc. H2SO4, acetic acid / 1 h / 50 °C
7: 70 percent / dimethyldioxirane / acetone / 0 °C
8: 81 percent / K2CO3 / acetone / Heating
9: 97 percent / AlCl3 / acetonitrile / 0.5 h / Ambient temperature
10: 96 percent / K2CO3 / methanol / 1.5 h / Heating
11: 74 percent / H2 / 10percent Pd/C / methanol; ethyl acetate / Ambient temperature
View Scheme
参考文献
Horie, Tokunaru; Shibata, Kenichi; Yamashita, Kazuyo; Kawamura, Yasuhiko; Tsukayama, Masao
Chemical and Pharmaceutical Bulletin, 1997 , vol. 45, # 3 p. 446 - 451
反应条件
1: 83 percent / K2CO3, KI / acetone; dimethylformamide / Heating
2: 75 percent / AlBr3, NaI / acetonitrile / 0.25 h / 0 °C
3: pyridine / 2 h / 70 - 80 °C
4: KOH / pyridine / 80 °C
5: 97 percent / conc. H2SO4, acetic acid / 1 h / 50 °C
6: 70 percent / dimethyldioxirane / acetone / 0 °C
7: 81 percent / K2CO3 / acetone / Heating
8: 97 percent / AlCl3 / acetonitrile / 0.5 h / Ambient temperature
9: 96 percent / K2CO3 / methanol / 1.5 h / Heating
10: 74 percent / H2 / 10percent Pd/C / methanol; ethyl acetate / Ambient temperature
View Scheme
参考文献
Horie, Tokunaru; Shibata, Kenichi; Yamashita, Kazuyo; Kawamura, Yasuhiko; Tsukayama, Masao
Chemical and Pharmaceutical Bulletin, 1997 , vol. 45, # 3 p. 446 - 451
反应条件
1: K2CO3 / dimethylformamide / 0.17 h / 150 °C
2: 100 percent / conc. HCl, acetic acid / 1 h / Ambient temperature
3: 83 percent / K2CO3, KI / acetone; dimethylformamide / Heating
4: 75 percent / AlBr3, NaI / acetonitrile / 0.25 h / 0 °C
5: pyridine / 2 h / 70 - 80 °C
6: KOH / pyridine / 80 °C
7: 97 percent / conc. H2SO4, acetic acid / 1 h / 50 °C
8: 70 percent / dimethyldioxirane / acetone / 0 °C
9: 81 percent / K2CO3 / acetone / Heating
10: 97 percent / AlCl3 / acetonitrile / 0.5 h / Ambient temperature
11: 96 percent / K2CO3 / methanol / 1.5 h / Heating
12: 74 percent / H2 / 10percent Pd/C / methanol; ethyl acetate / Ambient temperature
View Scheme
参考文献
Horie, Tokunaru; Shibata, Kenichi; Yamashita, Kazuyo; Kawamura, Yasuhiko; Tsukayama, Masao
Chemical and Pharmaceutical Bulletin, 1997 , vol. 45, # 3 p. 446 - 451
反应条件
1: pyridine / 2 h / 70 - 80 °C
2: KOH / pyridine / 80 °C
3: 97 percent / conc. H2SO4, acetic acid / 1 h / 50 °C
4: 70 percent / dimethyldioxirane / acetone / 0 °C
5: 81 percent / K2CO3 / acetone / Heating
6: 97 percent / AlCl3 / acetonitrile / 0.5 h / Ambient temperature
7: 96 percent / K2CO3 / methanol / 1.5 h / Heating
8: 74 percent / H2 / 10percent Pd/C / methanol; ethyl acetate / Ambient temperature
View Scheme
参考文献
Horie, Tokunaru; Shibata, Kenichi; Yamashita, Kazuyo; Kawamura, Yasuhiko; Tsukayama, Masao
Chemical and Pharmaceutical Bulletin, 1997 , vol. 45, # 3 p. 446 - 451
反应条件
1: 75 percent / AlBr3, NaI / acetonitrile / 0.25 h / 0 °C
2: pyridine / 2 h / 70 - 80 °C
3: KOH / pyridine / 80 °C
4: 97 percent / conc. H2SO4, acetic acid / 1 h / 50 °C
5: 70 percent / dimethyldioxirane / acetone / 0 °C
6: 81 percent / K2CO3 / acetone / Heating
7: 97 percent / AlCl3 / acetonitrile / 0.5 h / Ambient temperature
8: 96 percent / K2CO3 / methanol / 1.5 h / Heating
9: 74 percent / H2 / 10percent Pd/C / methanol; ethyl acetate / Ambient temperature
View Scheme
参考文献
Horie, Tokunaru; Shibata, Kenichi; Yamashita, Kazuyo; Kawamura, Yasuhiko; Tsukayama, Masao
Chemical and Pharmaceutical Bulletin, 1997 , vol. 45, # 3 p. 446 - 451
反应条件
1: 70 percent / dimethyldioxirane / acetone / 0 °C
2: 81 percent / K2CO3 / acetone / Heating
3: 97 percent / AlCl3 / acetonitrile / 0.5 h / Ambient temperature
4: 96 percent / K2CO3 / methanol / 1.5 h / Heating
5: 74 percent / H2 / 10percent Pd/C / methanol; ethyl acetate / Ambient temperature
View Scheme
参考文献
Horie, Tokunaru; Shibata, Kenichi; Yamashita, Kazuyo; Kawamura, Yasuhiko; Tsukayama, Masao
Chemical and Pharmaceutical Bulletin, 1997 , vol. 45, # 3 p. 446 - 451
反应条件
1: 81 percent / K2CO3 / acetone / Heating
2: 97 percent / AlCl3 / acetonitrile / 0.5 h / Ambient temperature
3: 96 percent / K2CO3 / methanol / 1.5 h / Heating
4: 74 percent / H2 / 10percent Pd/C / methanol; ethyl acetate / Ambient temperature
View Scheme
参考文献
Horie, Tokunaru; Shibata, Kenichi; Yamashita, Kazuyo; Kawamura, Yasuhiko; Tsukayama, Masao
Chemical and Pharmaceutical Bulletin, 1997 , vol. 45, # 3 p. 446 - 451
