反应条件
1: 1.) sodium nitrite, aq. HCl 2.) 50percent aq. KOH / 1.)ice-cooled 2.) ethanol, below 7 deg C, 30 min 2: 85 percent / PTSA / benzene / 2.5 h / Ambient temperature 3: 1.) hydrazine hydrate, KOH, triethylene glycol 2.) KOH / 1.) a) 150 deg C, 2 h b) 200 deg C, 2,5 h 2.) DMSO, RT 4: 88 percent / POCl3 / 6 h / 0 °C 5: 43 percent / POCl3 / 2 h / 60 °C 6: POCl3 / 6 h / 100 °C 7: 81 percent / 2 h / 100 °C 8: 1.) NaBH4 2.) Na2CO3 / 1.) MeOH, RT, 2 h 2.) THF-water, RT, 1.5 h 9: 53 percent / aq. HCl / dioxane / 2.5 h / Heating 10: 1.) Li 2.) 10percent Pd-C / 1.) liq. NH3-THF, 35 min 2.) tetralin, 210 deg C, 2 h View Scheme
参考文献
Yokoyama, Yuusaku; Okuyama, Naomi; Iwadate, Shinji; Momoi, Tokuko; Murakami, Yasuoki
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , # 5 p. 1319 - 1329
