2-羧基-3,4-二甲氧基苯甲醛合成路线 （共 87 条）
反应条件
1.1: n-BuLi / tetrahydrofuran / 0 °C 2.1: -78 °C 2.2: H2O / pH 2 View Scheme
参考文献
Morrison, Christopher F.; Burnell, D. Jean
Organic Letters, 2000 , vol. 2, # 24 p. 3891 - 3892
反应条件
1: T=-78°C; Carboxylation; 2: With water Hydrolysis; pH=2; Further stages. Title compound not separated from byproducts.;
参考文献
Morrison, Christopher F.; Burnell, D. Jean
Organic Letters, 2000 , vol. 2, # 24 p. 3891 - 3892
反应条件
1: p-toluenesulfonic acid / methanol / 1 h / Heating 2: 1) n-butyllithium / 1) ether, ice-water cooling, 1 h, 2) dry ice-acetone bath View Scheme
参考文献
Napolitano, Elio; Giannone, Enrico; Fiaschi, Rita; Marsili, Antonio
Journal of Organic Chemistry, 1983 , vol. 48, # 21 p. 3653 - 3657
反应条件
silver nitrate; trifluoroacetic anhydride in acetonitrile T=25°C;
参考文献
Manchukonda, Naresh K.; Sridhar, Balasubramanian; Naik, Pradeep K.; Joshi, Harish C.; Kantevari, Srinivas
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 8 p. 2983 - 2987
反应条件
manganese(IV) oxide; sulfuric acid
参考文献
Blyth
Justus Liebigs Annalen der Chemie, 1844 , vol. 50, p. 36
反应条件
silver nitrate; trifluoroacetic anhydride in acetonitrile T=25°C;
参考文献
Manchukonda, Naresh K.; Sridhar, Balasubramanian; Naik, Pradeep K.; Joshi, Harish C.; Kantevari, Srinivas
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 8 p. 2983 - 2987
反应条件
nitric acid T=50 - 60°C;
参考文献
Freund; Will
Chemische Berichte, 1886 , vol. 19, p. 2800
Chemische Berichte, 1887 , vol. 20, p. 90
反应条件
manganese(IV) oxide; sulfuric acid
参考文献
Blair et al.
Journal of the Chemical Society, 1955 , p. 708,711
反应条件
n-butyllithium 1) ether, ice-water cooling, 1 h, 2) dry ice-acetone bath; Yield given. Multistep reaction;
参考文献
Dong Chin Kim; Won Hyung Yoon; Choi; Kim
Journal of Heterocyclic Chemistry, 1993 , vol. 30, # 5 p. 1431 - 1436
反应条件
1: 3,4-Dimethoxybenzaldehyde dimethyl acetal With n-butyllithium in diethyl ether 1.08333 h; Cooling with iceInert atmosphere; 2: carbon dioxide in diethyl ether Cooling with dry iceInert atmosphere;
参考文献
Lowell, Andrew N.; Wall, Philip D.; Waters, Stephen P.; Kozlowski, Marisa C.
Tetrahedron, 2010 , vol. 66, # 30 p. 5573 - 5582
