α-乙酰基-γ-丁内酯合成路线 （共 116 条）
反应条件
trichlorophosphate
T=130°C;
参考文献
Ozawa et al.
Yakugaku Zasshi, 1959 , vol. 79, p. 230,233
Chem.Abstr., 1959 , p. 13147
反应条件
1: toluene-4-sulfonic acid
2: trichlorophosphate
View Scheme
参考文献
Pacquelet, Sandrine; Blache, Yves; Kimny, Tan; Dubois, Marie-Aleth Lacaille; Desbois, Nicolas
Synthetic Communications, 2013 , vol. 43, # 8 p. 1092 - 1100
反应条件
1: 70 percent / HBr
2: H(1+)
View Scheme
参考文献
Baldwin; Li
Journal of the Chemical Society - Series Chemical Communications, 1988 , # 4 p. 261 - 263
反应条件
sodium ethanolate in ethanol
Heating;
参考文献
Albrecht,R.; Schumann,K.
European Journal of Medicinal Chemistry, 1976 , vol. 11, p. 155 - 158
反应条件
1: NaOEt / ethanol / Heating
2: H2SO4 / 100 °C
View Scheme
参考文献
Albrecht,R.; Schumann,K.
European Journal of Medicinal Chemistry, 1976 , vol. 11, p. 155 - 158
反应条件
1: NaOEt / ethanol / Heating
2: H2SO4 / 100 °C
3: HNO3, H2SO4 / acetic anhydride / 0 °C
View Scheme
参考文献
Albrecht,R.; Schumann,K.
European Journal of Medicinal Chemistry, 1976 , vol. 11, p. 155 - 158
反应条件
thionyl chloride; sulfuric acid; magnesium in tetrachloromethane; ethanol; toluene
参考文献
Sumitomo Chemical Company, Limited
Patent: US4075346 A1, 1978 ;
反应条件
fluorine in formic acid
T=10 - 15°C;
参考文献
Chambers, Richard D.; Greenhall, Martin P.; Hutchinson, John
Tetrahedron, 1996 , vol. 52, # 1 p. 1 - 8
反应条件
1: sulfuryl dichloride / 20 °C
2: triethylamine tris(hydrogen fluoride); triethylamine / acetonitrile / 3 h / 80 °C
View Scheme
参考文献
H. Lundbeck A/S; Kilburn, John Paul; Rasmussen, Lars Kyhn; Jessing, Mikkel; Eldemenky, Eman Mohammed; Chen, Bin; Jiang, Yu; Hopper, Allen T.
Patent: US2014/107340 A1, 2014 ;
反应条件
1: sulfuryl dichloride / 20 °C
2: triethylamine tris(hydrogen fluoride); triethylamine / acetonitrile / 3 h / 80 °C
3: potassium iodide / 1-methyl-pyrrolidin-2-one / 190 °C / 375.04 Torr
View Scheme
参考文献
H. Lundbeck A/S; Kilburn, John Paul; Rasmussen, Lars Kyhn; Jessing, Mikkel; Eldemenky, Eman Mohammed; Chen, Bin; Jiang, Yu; Hopper, Allen T.
Patent: US2014/107340 A1, 2014 ;
