8-亚甲基-1,4-二噁螺[4.5]癸烷合成路线

参考文献

Frontier, Alison J.; Danishefsky, Samuel J.; Koppel, Gary A.; Meng, Dongfang
Tetrahedron, 1998 , vol. 54, # 42 p. 12721 - 12736

51656-90-78-亚甲基-1,4-二噁螺[4.5]癸烷

23521-81-5

参考文献

GALDERMA RESEARCH and DEVELOPMENT; CNRS
Patent: US2007/167519 A1, 2007 ;
Location in patent: Page/Page column 7; sheet 2 ;

51656-90-78-亚甲基-1,4-二噁螺[4.5]癸烷+

75-11-6二碘甲烷

15811-21-9螺[2.5]-6-辛酮

参考文献

Mihovilovic; Chen; Wang; Kyte; Rochon; Kayser; Stewart
Journal of Organic Chemistry, 2001 , vol. 66, # 3 p. 733 - 738

51656-90-78-亚甲基-1,4-二噁螺[4.5]癸烷

15811-21-9螺[2.5]-6-辛酮

参考文献

Bolli, Martin H.; Velker, Joerg; Mueller, Claus; Mathys, Boris; Birker, Magdalena; Bravo, Roberto; Bur, Daniel; De Kanter, Ruben; Hess, Patrick; Kohl, Christopher; Lehmann, David; Meyer, Solange; Nayler, Oliver; Rey, Markus; Scherz, Michael; Steiner, Beat
Journal of Medicinal Chemistry, 2014 , vol. 57, # 1 p. 78 - 97

51656-90-78-亚甲基-1,4-二噁螺[4.5]癸烷

118537-39-6

参考文献

Rosowsky, Andre; Forsch, Ronald A.; Moran, Richard G.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 3 p. 709 - 715

51656-90-78-亚甲基-1,4-二噁螺[4.5]癸烷

93245-98-81,4-二噁螺[4.5]癸烷-8-甲醛

参考文献

Rosowsky, Andre; Forsch, Ronald A.; Moran, Richard G.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 3 p. 709 - 715

51656-90-78-亚甲基-1,4-二噁螺[4.5]癸烷+

624-73-71,2-二碘乙烷

52875-47-5

参考文献

ACTELION PHARMACEUTICALS LTD
Patent: WO2006/100631 A1, 2006 ;
Location in patent: Page/Page column 71-72 ;

186581-53-3重氮甲烷+

51656-90-78-亚甲基-1,4-二噁螺[4.5]癸烷

52875-47-5

参考文献

BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BROCHU, Christian; GRAND-MAÎTRE, Chantal; FADER, Lee; KUHN, Cyrille; BERTRAND-LAPERLE, Mégan; PESANT, Marc
Patent: WO2013/26163 A1, 2013 ;
Location in patent: Page/Page column 34 ;

51656-90-78-亚甲基-1,4-二噁螺[4.5]癸烷+

75-11-6二碘甲烷

52875-47-5

参考文献

Bolli, Martin H.; Velker, Joerg; Mueller, Claus; Mathys, Boris; Birker, Magdalena; Bravo, Roberto; Bur, Daniel; De Kanter, Ruben; Hess, Patrick; Kohl, Christopher; Lehmann, David; Meyer, Solange; Nayler, Oliver; Rey, Markus; Scherz, Michael; Steiner, Beat
Journal of Medicinal Chemistry, 2014 , vol. 57, # 1 p. 78 - 97

4746-97-81,4-环己二酮单乙二醇缩酮+

1779-49-3甲基三苯基溴化膦

51656-90-78-亚甲基-1,4-二噁螺[4.5]癸烷

参考文献

Frontier, Alison J.; Danishefsky, Samuel J.; Koppel, Gary A.; Meng, Dongfang
Tetrahedron, 1998 , vol. 54, # 42 p. 12721 - 12736