N-(5-氨基戊基)氨基甲酸叔丁酯合成路线 （共 19 条）
反应条件
in chloroform 2 h; Ambient temperature;
参考文献
Pons, Jean-Francois; Fauchere, Jean-Luc; Lamaty, Frederic; Molla, Annie; Lazaro, Rene
European Journal of Organic Chemistry, 1998 , # 5 p. 853 - 859
反应条件
ammonia; hydrogen; nickel in ethanol T=50°C; P=15514.4 Torr; 8 h;
参考文献
Houssin, Raymond; Bernier, Jean-Luc; Henichart, Jean-Pierre
Synthesis, 1988 , # 3 p. 259 - 261
反应条件
in 1,4-dioxane 22 h;
参考文献
Fletcher, David I.; Ganellin, C. Robin; Piergentili, Alessandro; Dunn, Philip M.; Jenkinson, Donald H.
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 16 p. 5457 - 5479
反应条件
hydrogen; palladium on activated charcoal in methanol 1 h; Ambient temperature;
参考文献
Arasujo, M. Joso S. M. P.; Ragnarsson, Ulf; Trigo, M. Joaquina S. A. Amaral; Almeida, M. Lurdes S.
Journal of Chemical Research, Miniprint, 1996 , # 8 p. 2143 - 2161
反应条件
hydrogenchloride; sodium hydroxide in water; tert-butyl alcohol
参考文献
SmithKline Beckman Corporation
Patent: US4543349 A1, 1985 ;
反应条件
in ethanol T=65°C; 16 h; Inert atmosphere;
参考文献
Harvey, Jessica H.; Long, Darcie H.; Whistler, Jennifer L.; England, Pamela M.
Medicinal Chemistry letters, 2012 , vol. 3, # 8 p. 640 - 644,5
Title/Abstract Full Text Show Details
Harvey, Jessica H.; Long, Darcie H.; England, Pamela M.; Whistler, Jennifer L.
ACS Medicinal Chemistry Letters, 2012 , vol. 3, # 8 p. 640 - 644
反应条件
in tetrahydrofuran T=0°C; 0.166667 h;
参考文献
McWatt, Martin; Boons, Geert-Jan
European Journal of Organic Chemistry, 2001 , # 13 p. 2535 - 2545
反应条件
hydrogen; platinum(IV) oxide in ethanol
参考文献
Miyashita, Masaaki; Saito, Hiroaki; Matsushita, Masayuki; Miyazawa, Masahiro; Itagaki, Yasuhiro; Nakajima, Terumi
Tetrahedron Letters, 1997 , vol. 38, # 48 p. 8297 - 8298
反应条件
1: 75 percent / 1N aq. NaOH / dioxane / 0 deg C to room temp., 2: 1.) Et3N, ethyl carbonochloridate, 2.) 20percent aq. NH3 / 1.) THF, -10 deg C, 20 min., 2.) -10 deg C to room temp., overnight 3: 53 percent / Et3N, trifluoroacetic anhydride / tetrahydrofuran / 1 h / 0 deg C to room temp., 4: 60 percent / NH3, H2 / Raney Ni / ethanol / 8 h / 50 °C / 15514.4 Torr View Scheme
参考文献
Houssin, Raymond; Bernier, Jean-Luc; Henichart, Jean-Pierre
Synthesis, 1988 , # 3 p. 259 - 261
反应条件
1: 1.) Et3N, ethyl carbonochloridate, 2.) 20percent aq. NH3 / 1.) THF, -10 deg C, 20 min., 2.) -10 deg C to room temp., overnight 2: 53 percent / Et3N, trifluoroacetic anhydride / tetrahydrofuran / 1 h / 0 deg C to room temp., 3: 60 percent / NH3, H2 / Raney Ni / ethanol / 8 h / 50 °C / 15514.4 Torr View Scheme
参考文献
Houssin, Raymond; Bernier, Jean-Luc; Henichart, Jean-Pierre
Synthesis, 1988 , # 3 p. 259 - 261
