5-氯-2-(吡啶-4-基)苯并[d]噻唑合成路线 （共 5 条）
反应条件
sulfur in neat (no solvent)
T=120°C; 24 h; Sealed tubeInert atmosphere;
参考文献
Nguyen, Thanh Binh; Ermolenko, Ludmila; Al-Mourabit, Ali
Organic Letters, 2013 , vol. 15, # 16 p. 4218 - 4221
参考文献
Merck Sharp and Dohme, Ltd.
Patent: US5849765 A1, 1998 ;
US 5849765 A
反应条件
in dimethyl sulfoxide
T=200°C; Yield given;
参考文献
Haworth; Harrison; Kulagowski; Leeson; Owens; Ridgill; Teall; Fielding; Chapman; Emms; Marwood; Patel; Moss
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 17 p. 2211 - 2216
反应条件
sodium hydroxide; potassium carbonate; potassium hexacyanoferrate(III)
1.) water, 60-70 deg C, 4 h, 2.) water, 50-60 deg C, 1 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Hisano; Ichikawa; Tsumoto; Tasaki
Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 8 p. 2996 - 3004
参考文献
Farbenfabr. Bayer
Patent: DE930926 , 1953 ;
