1: 90 percent / Raney nickiel / aq. ethanol / Heating 2: 0.5 h / 145 °C 3: 0.52 g / POCl3 / 2 h / Heating View Scheme

hydrogen; nickel in methanol P=3620.13 Torr;

1: (trans)-β-nitrostyrene With 2-[(S)-4-isopropyl-4,5-dihydrooxazol-2-yl]-N-[2-(-4-phenyl-4,5-dihydrothiazol-2-yl)phenyl]benzenamine; zinc trifluoromethanesulfonate in toluene T=20°C; 0.166667 h; Inert atmosphere; 2: indole in toluene T=-20°C; Friedel Crafts alkylation; 15 h; Inert atmosphere;

2,2,2-trifluoroethanol; 1-(3,5-bis(trifluoromethyl)phenyl)-3-(2-(difluoroboryl)phenyl)urea in dichloromethane T=23°C; 24 h; Inert atmosphere; Kinetics; Reagent/catalyst;

(CuOTf)2.C6H6; hexafluoroisopropyl alcohol; 2-{[(1S)-N-{[(4S,5S)-4,5-dihydro-4,5-diphenyl-1-tosyl-1H-imidazol-2-yl]methyl}-1-phenylethanamino]methyl}-4,6-dibromophenol in toluene T=0°C; 17 h; Inert atmosphere; optical yield given as percent dediastereoselective reaction;

1: sodium hydroxide / methanol; water / 1 h / 0 - 5 °C 2: Zn(CH3COO)2*2H2O / cyclohexane / 14 h / 80 °C View Scheme

samarium (III) iodide; silica gel Michael reaction; 0.0333333 h; microwave irradiation;