20Alpha-羟基胆固醇合成路线 （共 10 条）
反应条件
1: 1-bromo-4-methyl-pentane With magnesium; iodine Inert atmosphere; 2: (3β)-3-hydroxypregn-5-en-20-one 0.166667 h; 3: With hydrogenchloride; water
参考文献
Kim, Kyeojin; Maharjan, Sony; Lim, Changjin; Kim, Nam-Jung; Agrawal, Vijayendra; Han, Young Taek; Lee, Sujin; An, Hongchan; Yun, Hwayoung; Choi, Hyun-Jung; Kwon, Young-Guen; Suh, Young-Ger
European Journal of Medicinal Chemistry, 2014 , vol. 75, p. 184 - 194
参考文献
Stappenbeck, Frank; Xiao, Wei; Epperson, Matt; Riley, Mariko; Priest, Aaron; Huang, Danwen; Scott Thies, R.; Farouz, Francine; Nguyen, Khanhlinh; Jung, Michael E.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 18 p. 5893 - 5897,5
反应条件
1: SmI2 / tetrahydrofuran; hexamethylphosphoric acid triamide / Ambient temperature 2: Bu4NF / tetrahydrofuran / 12 h / Ambient temperature View Scheme
参考文献
Stappenbeck, Frank; Xiao, Wei; Epperson, Matt; Riley, Mariko; Priest, Aaron; Huang, Danwen; Scott Thies, R.; Farouz, Francine; Nguyen, Khanhlinh; Jung, Michael E.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 18 p. 5893 - 5897,5
反应条件
1: SmI2 / tetrahydrofuran; hexamethylphosphoric acid triamide / Ambient temperature 2: Bu4NF / tetrahydrofuran / 12 h / Ambient temperature View Scheme
参考文献
Velgova,H. et al.
Collection of Czechoslovak Chemical Communications, 1969 , vol. 34, p. 3354 - 3376
反应条件
1: |Alkaline conditions; |Inert atmosphere 2: n-butyllithium / tetrahydrofuran / -10 °C / |Inert atmosphere 3: hydrogen; 10 Pd/C / dichloromethane; ethyl acetate View Scheme
参考文献
Stappenbeck, Frank; Xiao, Wei; Epperson, Matt; Riley, Mariko; Priest, Aaron; Huang, Danwen; Scott Thies, R.; Farouz, Francine; Nguyen, Khanhlinh; Jung, Michael E.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 18 p. 5893 - 5897,5
反应条件
10 Pd/C; hydrogen in dichloromethane; ethyl acetate
参考文献
Stappenbeck, Frank; Xiao, Wei; Epperson, Matt; Riley, Mariko; Priest, Aaron; Huang, Danwen; Scott Thies, R.; Farouz, Francine; Nguyen, Khanhlinh; Jung, Michael E.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 18 p. 5893 - 5897,5
反应条件
sulfuric acid in acetone
参考文献
Velgova,H. et al.
Collection of Czechoslovak Chemical Communications, 1969 , vol. 34, p. 3354 - 3376
反应条件
1: (i) Mg, I2, THF, (ii) /BRN= 6794285/ 2: aq. H2SO4 / acetone View Scheme
参考文献
Velgova,H. et al.
Collection of Czechoslovak Chemical Communications, 1969 , vol. 34, p. 3354 - 3376
反应条件
lithium 3.) EtNH2, reflux, 2 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Honda; Komori
Tetrahedron Letters, 1986 , vol. 27, # 29 p. 3369 - 3372
反应条件
anschliessend Hydrolyse;
参考文献
Petrow; Stuart-Webb
Journal of the Chemical Society, 1956 , p. 4675
Full Text Show Details
Mijares et al.
Journal of Organic Chemistry, 1967 , vol. 32, p. 810
