11-Beta,17-alpha,21-三羟基-5-alpha-孕烯-3,20-二酮合成路线 （共 10 条）
反应条件
sodium methylate in methanol T=20°C; 1 h;
参考文献
Okihara, Rika; Mitamura, Kuniko; Hasegawa, Maki; Mori, Megumi; Muto, Akina; Kakiyama, Genta; Ogawa, Shoujiro; Iida, Takashi; Shimada, Miki; Mano, Nariyasu; Ikegawa, Shigeo
Chemical and Pharmaceutical Bulletin, 2010 , vol. 58, # 3 p. 344 - 353
反应条件
in ethanol T=24 - 26°C; 96 h; Penicillium decumbens ATCC 10436, potato dextrose broth;
参考文献
Holland, Herbert L.
Steroids, 1995 , vol. 60, # 9 p. 646 - 649
反应条件
1: 1.5 g / p-toluenesulfonic acid / ethanol; tetrahydrofuran / 4.5 h / Ambient temperature 2: 1.) H2, 2.) 2 N HCl / 1.) 5percent Pd-C / 1.) ethyl acetate, ethanol, 14 h, atmospheric pressure 3: NaOH / methanol View Scheme
参考文献
Hosoda; Osanai; Fukasawa; Nambara
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 7 p. 1949 - 1952
反应条件
1: 1.) H2, 2.) 2 N HCl / 1.) 5percent Pd-C / 1.) ethyl acetate, ethanol, 14 h, atmospheric pressure 2: NaOH / methanol View Scheme
参考文献
Hosoda; Osanai; Fukasawa; Nambara
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 7 p. 1949 - 1952
反应条件
3-Methylpyridine; 5 palladium on charcoal; hydrogen T=25°C; 24 h; Reagent/catalyst; Overall yield = 97 percent; stereoselective reaction;
参考文献
Ramachary, Dhevalapally B.; Sakthidevi, Rajasekar; Reddy, P. Srinivasa
RSC Advances, 2013 , vol. 3, # 32 p. 13497 - 13506
参考文献
Evans et al.
Journal of the Chemical Society, 1958 , p. 1529,1536
反应条件
1: toluene-4-sulfonic acid-hydrate 2: sodium borate; aqueous methanol 3: aqueous methanol.H2SO4 View Scheme
参考文献
Evans et al.
Journal of the Chemical Society, 1958 , p. 1529,1536
3751-02-8[2-(17-羟基-10,13-二甲基-3,11-二氧代-1,2,4,5,6,7,8,9,12,14,15,16-十二氢环戊烯并[a]菲-17-基)-2-氧代乙基]乙酸酯
→
反应条件
1: aqueous methanol.KOH 2: toluene-4-sulfonic acid-hydrate 3: sodium borate; aqueous methanol 4: aqueous methanol.H2SO4 View Scheme
参考文献
Evans et al.
Journal of the Chemical Society, 1958 , p. 1529,1536
反应条件
1: sodium borate; aqueous methanol 2: aqueous methanol.H2SO4 View Scheme
参考文献
Evans et al.
Journal of the Chemical Society, 1958 , p. 1529,1536
参考文献
Evans et al.
Journal of the Chemical Society, 1958 , p. 1529,1536
