sodium hydroxide; urea in water; ethyl acetate

sodium chlorite; sodium carbonate in water; ethyl acetate T=25°C; 6.5 h; or oxidation with Br2;

sodium sulfide in tetrahydrofuran T=20°C; Substitution; 3 h;

potassium tert-butylate; hydrogen in toluene T=25°C; P=76005.1 Torr; 12 h; Autoclave; optical yield given as percent eeenantioselective reaction;

[Ru(II)(η6-benzene)(μ-Cl)Cl]2; C33H48OP2; potassium tert-butylate; hydrogen in toluene T=110°C; P=76005.1 Torr; 32 h; Autoclave; optical yield given as percent eeenantioselective reaction;

1: 84 percent / conc. HCl / dioxane / 2.5 h / Ambient temperature 2: 2) 6.25percent aq. HCl / 1) acetone, water 3: 87 percent / NaClO2, Na2CO3 / H2O; ethyl acetate / 6.5 h / 25 °C / or oxidation with Br2 View Scheme

1: 2) 6.25percent aq. HCl / 1) acetone, water 2: 87 percent / NaClO2, Na2CO3 / H2O; ethyl acetate / 6.5 h / 25 °C / or oxidation with Br2 View Scheme

暂无反应条件数据

1: (i) , (ii) Zn, AcOH 2: (i) H2S, (ii) Zn, HCl View Scheme

1.1: methanesulfonic acid / toluene / 4 h / Reflux; Inert atmosphere 2.1: 3-(3,5-bis-trifluoromethyl-phenylamino)-4-{[(S)-(6-methoxy-quinolin-4-yl)-((R)-5-vinyl-1-aza-bicyclo[2.2.2]oct-2-yl)-methyl]-amino}-cyclobut-3-ene-1,2-dione / tert-butyl methyl ether / 24 h / 25 °C / Inert atmosphere 3.1: calcium chloride / ethanol / 0 - 25 °C / Inert atmosphere 4.1: hydrogenchloride / water / 0.5 h / 55 °C / Inert atmosphere 5.1: PhCOSK / N,N-dimethyl-formamide / 2 h / 150 °C / Inert atmosphere 6.1: iodine; magnesium / tetrahydrofuran / 1 h / Inert atmosphere; Reflux 6.2: 2 h / Reflux; Inert atmosphere 6.3: 3 h / Reflux 7.1: palladium 10 on activated carbon; hydrogen / isopropyl alcohol / 12 h / 110 °C / 45603.1 Torr 8.1: hydrogenchloride; formic acid / water / 5 h / Reflux; Inert atmosphere 9.1: dimethyl sulfoxide / 3 h / 90 °C / Inert atmosphere 10.1: water; hydrogen bromide / 10 h / Reflux; Inert atmosphere View Scheme